Plasmodium malariae and plasmodium ovale genes and uses thereof

• US 8,268,981 B2
• Filed: 03/04/2009
• Issued: 09/18/2012
• Est. Priority Date: 03/06/2008
• Status: Active Grant

• Current Assignee: Abbott Laboratories Incorporated
• Original Assignee: Abbott Laboratories Incorporated
• Inventors: Birkenmeyer, Larry G., Muerhoff, Anthony S., Desai, Suresh M., Dawson, George J., Dille, Bruce J.
• Primary Examiner(s): Ford, Vanessa L.
• Assistant Examiner(s): TONGUE, LAKIA J
• Application Number:
  US12/397,558
• Publication Number:
  US 20090232797A1
• Time in Patent Office: 1,294 Days
• Field of Search: None
• US Class Current: 536/23.7
• CPC Class Codes: A61K 39/00 Medicinal preparations containing antigens or antibodies materials for immunoassay G01N33/53
• CPC Class Codes: C07K 14/445 Plasmodium
• CPC Class Codes: G01N 2333/445 Plasmodium
• CPC Class Codes: G01N 2469/20 Detection of antibodies in sample from host which are directed against antigens from microorganisms
• CPC Class Codes: G01N 33/56905 Protozoa
• CPC Class Codes: Y02A 50/30 Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The subject invention relates to nucleic acid sequences and amino acid sequences encoded thereby, derived from the Merozoite Surface Protein (MSP1) gene of the Plasmodium species P. malariae and P. ovale. Such genes and proteins have many beneficial diagnostic as well as therapeutic uses.

Claims

1. An isolated nucleic acid sequence comprising a nucleotide sequence encoding a polypeptide, wherein the amino acid sequence of said polypeptide has at least 90% identity to an amino acid sequence selected from the group consisting of SEQ ID NO:

3, amino acids 1614-1712 of SEQ ID NO;

3, amino acids 1347-1613 of SEQ ID NO;

3 and amino acids 1347-1712 of SEQ ID NO;

3.

2. The isolated nucleic acid sequence of claim 1, wherein said sequence is isolated from Plasmodium ovale.