Modular drug delivery system for minimizing trauma during and after insertion of a cochlear lead
First Claim
1. A system for delivering a therapeutic agent to biological tissue comprising:
- a surgically implantable lead configured to be inserted into said biological tissue, said surgically implantable lead comprising a coating containing said therapeutic agent, said therapeutic agent comprising mixed DXMb and DEX salt;
said coating releasing said therapeutic agent into said biological tissue, wherein said therapeutic agent comprises DXMb coupled to said surgically implantable lead, DEX salt deposited over said DXMb, wherein said DEX salt is configured to rapidly elute into said biological tissue when said surgically implantable lead is implanted and said DXMb is configured to more slowly elute into said biological tissue at a lower concentration than said DEX salt.
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Accused Products
Abstract
A system for delivering therapeutic agents to biological tissue includes a surgically implantable lead configured to be inserted into the biological tissue, the surgically implantable lead including a preformed cavity; and a modular capsule containing a therapeutic agent which includes dexamethasone base; the modular capsule being secured within the preformed cavity; the modular capsule releasing the therapeutic agent into the biological tissue. A method of delivering therapeutic agents to biological tissue includes obtaining a surgically implantable lead with a preformed cavity; obtaining a modular capsule containing a therapeutic agent comprising dexamethasone base and securing it within the preformed cavity; and inserting the surgically implantable lead into the biological tissue.
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Citations
12 Claims
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1. A system for delivering a therapeutic agent to biological tissue comprising:
a surgically implantable lead configured to be inserted into said biological tissue, said surgically implantable lead comprising a coating containing said therapeutic agent, said therapeutic agent comprising mixed DXMb and DEX salt;
said coating releasing said therapeutic agent into said biological tissue, wherein said therapeutic agent comprises DXMb coupled to said surgically implantable lead, DEX salt deposited over said DXMb, wherein said DEX salt is configured to rapidly elute into said biological tissue when said surgically implantable lead is implanted and said DXMb is configured to more slowly elute into said biological tissue at a lower concentration than said DEX salt.- View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A system for delivering a therapeutic agent to biological tissue comprising:
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a surgically implantable lead configured to be inserted into the biological tissue; an inner layer comprising dexamethasone base (DXMb) deposited on the lead; and an outer layer comprising dexamethasone salt (DEX salt) deposited on the inner layer wherein said DEX salt is configured to rapidly elute into surrounding tissue when the device is implanted and said DXMb is configured to more slowly elute into said surrounding tissue at a lower concentration than the DEX salt. - View Dependent Claims (10, 11, 12)
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Specification