Pressure recovery index to assess cardiac function

• US 8,273,029 B2
• Filed: 02/17/2009
• Issued: 09/25/2012
• Est. Priority Date: 02/18/2008
• Status: Active Grant

• Current Assignee: Washington University In St Louis
• Original Assignee: Washington University In St Louis
• Inventors: Kovacs, Sandor J., Shmuylovich, Leonid, Zhang, Wei, Chung, Charles
• Primary Examiner(s): Gabel, Gail R
• Application Number:
  US12/372,512
• Publication Number:
  US 20090209869A1
• Time in Patent Office: 1,316 Days
• Field of Search: 600/479, 600/480, 600/481, 600/485, 600/486, 600/508, 600/516, 600/517, 600/526
• US Class Current: 600/481
• CPC Class Codes: A61B 5/0215 by means inserted into the body catheters A61M25/00
• CPC Class Codes: G16H 50/30 for calculating health indices; for individual health risk assessment
• CPC Class Codes: G16H 50/50 for simulation or modelling of medical disorders

Abstract

Determining an index for assessing cardiac function. In an embodiment, a method includes receiving ventricular pressure data during an invasive cardiac procedure, wherein the received pressure data includes a diastatic ventricular pressure value, a minimum ventricular pressure value, and a predefined fiducial marker pressure value. An index value is calculated by comparing a first pressure difference to a second pressure difference. The first pressure difference represents the difference between the received diastatic ventricular pressure value and the received minimum ventricular pressure value. The second pressure difference represents the difference between the received fiducial marker pressure value and the received minimum ventricular pressure value. The index value is provided to a health care provider to assess early diastolic cardiac function.

Claims

1. A method for assessing cardiac function, said method comprising:

obtaining ventricular pressure data from a subject during an invasive cardiac procedure, said received pressure data comprising a diastatic ventricular pressure value, a minimum ventricular pressure value, and a predefined fiducial marker pressure value;

determining a first pressure difference between the received diastatic ventricular pressure value and the received minimum ventricular pressure value;

determining a second pressure difference between the received fiducial marker pressure value and the received minimum ventricular pressure value, wherein the fiducial marker pressure value corresponds to one or more of the following;

an end diastolic pressure value, and a pressure value at the steepest slope of a pressure contour derived from the ventricular pressure data;

comparing the first pressure difference with the second pressure difference to generate an index value indicative of early diastolic cardiac function, wherein the index value is based on a ratio of the first pressure difference to the second pressure difference; and

providing the generated index value to a health care provider to provide an assessment of cardiac function in the subject.

2. The method of claim 1, wherein said determining the first pressure difference, said determining the second pressure difference, said comparing, and said providing occur during or after the invasive cardiac procedure to enable the health care provided to dynamically assess cardiac function.

3. The method of claim 1, wherein receiving the ventricular pressure data comprises receiving left ventricular pressure data sampled over time.

4. The method of claim 1, wherein the generated index is based on one or more of the following:

ventricular diastolic function, ventricular viscoelasticity, ventricular relaxation, presence or absence of a delayed relaxation pattern, valvular function, ventricular efficiency, and ventricular energetics.

5. The method of claim 1, wherein receiving the ventricular pressure data comprises receiving running averages of each of the diastatic ventricular pressure value, the minimum ventricular pressure value, and the predefined fiducial marker pressure value.

6. The method of claim 1, wherein obtaining ventricular pressure data comprises receiving a first set of ventricular pressure data, said method further comprising:

storing the generated index;

obtaining a second set of ventricular pressure data from the subject;

determining the first and second pressure differences as a function of the received second set of ventricular pressure data;

comparing the first and second pressure differences to generate a second index value;

averaging the index value and the second index value; and

providing the averaged index value to the health care provider.