Ocular implant with anchor and therapeutic agent

• US 8,273,050 B2
• Filed: 07/12/2004
• Issued: 09/25/2012
• Est. Priority Date: 04/14/2000
• Status: Expired due to Fees

• Current Assignee: Glaukos Corporation
• Original Assignee: Glaukos Corporation
• Inventors: Bergheim, Olav B., Gharib, Morteza (Mory)
• Primary Examiner(s): Zalukaeva, Tatyana
• Assistant Examiner(s): MARCETICH, ADAM M
• Application Number:
  US10/889,254
• Publication Number:
  US 20040249333A1
• Time in Patent Office: 2,997 Days
• Field of Search: 606/6, 606/109, 606/153, 606/8, 606/9, 606/284, 606/30, 606/264, 606/108, 427/2.24, 427/2, 427/24, 604/8, 604/9, 604/284, 604/30, 604/264, 604/294, 623/4.1
• US Class Current: 604/8
• CPC Class Codes: A61F 2009/00891 Glaucoma
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61F 9/0017 implantable in, or in contact with, the eye, e.g. ocular inserts
• CPC Class Codes: A61F 9/007 Methods or devices for eye surgery
• CPC Class Codes: A61F 9/00781 Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment drainage implants in general A61M27/002
• CPC Class Codes: A61K 9/0051 Ocular inserts, ocular implants
• CPC Class Codes: A61M 2210/0612 Eyes
• CPC Class Codes: A61M 27/002 Implant devices for drainage of body fluids from one part of the body to another intraocular A61F9/00781; middle ear A61F11/202
• CPC Class Codes: A61P 27/06 Antiglaucoma agents or miotics
• CPC Class Codes: Y10S 623/905 Eye

Abstract

Ocular implants and methods of treating ocular disorders are provided. One method involves inserting an implant into an anterior chamber of an eye. The implant has a therapeutic drug or agent and is advanced within the anterior chamber to a location posterior to a cornea of the eye. At least a portion of the implant is placed into eye tissue at this location. The therapeutic drug of the implant is exposed to aqueous humor. In one method, an anchor is utilized to retain the implant in eye tissue.

Claims

1. An implant for treating an ocular disorder, comprising:

a body having a first end portion configured to be positioned in an anterior chamber of an eye when implanted, the first end portion comprising at least one inlet opening and having a first axis defined therethrough, and a second end portion configured to be positioned in a physiologic outflow pathway of the eye when implanted, the second end portion comprising at least one outlet opening and having a second axis defined therethrough, wherein the at least one inlet opening and the at least one outlet opening are in fluid communication;

an anchor disposed on the second end portion configured to be positioned in the physiologic outflow pathway and extending substantially perpendicularly to the second axis without extending beyond the physiologic outflow pathway, and

a therapeutic agent carried by the body.

2. The implant of claim 1, wherein the body comprises a tube.

3. The implant of claim 1, wherein the body has a lumen with an oval cross-section.

4. The implant of claim 1, wherein the at least one outlet opening comprises two outlet openings positioned in the body such that the anchor is located between the outlet openings.

5. The implant of claim 1, wherein the at least one outlet opening comprises two outlet openings and one of the outlet openings is located substantially at an intersection between the first and second end portions.

6. The implant of claim 1, wherein the first axis is substantially perpendicular to the second axis.

7. The implant of claim 1, wherein the anchor extends on plural sides of the body.

8. The implant of claim 1, wherein the therapeutic agent is part of the body of the implant.

9. The implant of claim 1, wherein the body is coated with the therapeutic agent.

10. The implant of claim 1, wherein the body includes a first portion and a second portion that is appended from the first portion, and wherein the first portion includes a lumen and the second portion carries the therapeutic agent.

11. The implant of claim 1, wherein the at least one outlet opening comprises multiple outlet openings.

12. The implant of claim 1, wherein the physiologic outflow pathway comprises Schlemm'"'"'s canal.

13. The implant of claim 1, wherein the body comprises a curved lumen.

14. The implant of claim 1, wherein the body comprises a flexible lumen.

15. An implant for treating an ocular disorder, comprising:

a body having a first end portion configured to be positioned in an anterior chamber of an eye when implanted, the first end portion comprising at least one inlet opening and having a first axis defined therethrough, and a second end portion configured to be positioned in a physiologic outflow pathway of the eye when implanted, the second end portion comprising two outlet openings and having a second axis defined therethrough, wherein the inlet opening and the two outlet openings are in fluid communication;

an anchor disposed on the second end portion configured to be positioned in the physiologic outflow pathway when implanted and extending substantially perpendicularly to the second axis without extending beyond the physiologic outflow pathway; and

a therapeutic agent carried by the body.

16. The implant of claim 15, wherein the therapeutic agent is part of the body of the implant.

17. The implant of claim 15, wherein the body is coated with the therapeutic agent.

18. The implant of claim 15, wherein the body includes a first portion and a second portion that is appended from the first portion, and wherein the first portion includes a lumen and the second portion carries the therapeutic agent.

19. The implant of claim 15, wherein the body comprises a tube.

20. The implant of claim 15, wherein the body has a lumen with an oval cross-section.

21. The implant of claim 15, wherein the two outlet openings are positioned in the body such that the anchor is located between the two outlet openings.

22. The implant of claim 15, wherein one of the outlet openings is located substantially at an intersection between the first and second end portions.

23. The implant of claim 15, wherein the second axis is substantially perpendicular to the first axis.

24. The implant of claim 15, wherein the physiologic outflow pathway comprises Schlemm'"'"'s canal.

25. The implant of claim 15, wherein the body comprises a curved lumen.

26. The implant of claim 15, wherein the body comprises a flexible lumen.