Modular system for radiosynthesis with multi-run capabilities and reduced risk of radiation exposure
First Claim
Patent Images
1. An instrument for synthesis of radiolabeled compounds comprising:
- one or more “
hot”
component units; and
at least one “
cold”
component unit;
wherein the one or more “
hot”
component units and the at least one “
cold”
component unit are separate units that are operatively connected to each other, and the one or more “
hot”
component units and the at least one “
cold”
component unit being positioned from each other to reduce radiation exposure to a user and sensitive equipment, andwherein the at least one “
cold”
component unit has reagents and every reagent is continuously accessible.
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Accused Products
Abstract
Macro- and microfluidic devices and related technologies, and chemical processes using such devices. More specifically, the devices may be used for a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in an efficient, compact and safe to the operator manner. In particular, embodiments of the present invention relate to an automated, multi-run, microfluidic instrument for the multi-step synthesis of radiopharmaceuticals, such as PET probes, comprising a remote shielded mini-cell containing radiation-handing components.
52 Citations
51 Claims
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1. An instrument for synthesis of radiolabeled compounds comprising:
-
one or more “
hot”
component units; andat least one “
cold”
component unit;wherein the one or more “
hot”
component units and the at least one “
cold”
component unit are separate units that are operatively connected to each other, and the one or more “
hot”
component units and the at least one “
cold”
component unit being positioned from each other to reduce radiation exposure to a user and sensitive equipment, andwherein the at least one “
cold”
component unit has reagents and every reagent is continuously accessible. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 39, 40, 41, 42, 43, 44)
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35. A method of conducting radiosynthesis of a radiolabeled compound comprising:
-
providing one or more “
hot”
component units; andproviding at least one “
cold”
component unit;wherein the one or more “
hot”
component units and the at least one “
cold”
component unit are separate units that are operatively connected to each other, and the one or more “
hot”
component units and the at least one “
cold”
component unit being positioned from each other to reduce radiation exposure to a user and sensitive equipment, andwherein the at least one “
cold”
component unit has reagents and every reagent is continuously accessible. - View Dependent Claims (36, 37, 38)
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45. An instrument for synthesis of radiolabeled compounds comprising:
-
one or more “
hot”
component units; andat least one “
cold”
component unit;wherein the one or more “
hot”
component units and the at least one “
cold”
component unit are separate units that are operatively connected to each other, and the one or more “
hot”
component units and the at least one “
cold”
component unit being positioned from each other to reduce radiation exposure to a user and sensitive equipment,wherein at least one of the one or more “
hot”
component units has radiation-handling components and the at least one of the one or more “
hot”
component units is placed inside a mini-cell, andwherein the at least one “
cold”
component unit has reagents and the at least one “
cold”
component unit is placed outside the mini-cell so as to allow access to the reagents between runs.
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46. An instrument for synthesis of radiolabeled compounds comprising:
-
one or more “
hot”
component units; andat least one “
cold”
component unit;wherein the one or more “
hot”
component units and the at least one “
cold”
component unit are separate units that are operatively connected to each other, and the one or more “
hot”
component units and the at least one “
cold”
component unit being positioned from each other to reduce radiation exposure to a user and sensitive equipment,wherein at least one of the one or more “
hot”
component units includes one or more microfluidic chips.
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47. An instrument for synthesis of radiolabeled compounds comprising:
-
one or more “
hot”
component units; andat least one “
cold”
component unit;wherein the one or more “
hot”
component units and the at least one “
cold”
component unit are separate units that are operatively connected to each other, and the one or more “
hot”
component units and the at least one “
cold”
component unit being positioned from each other to reduce radiation exposure to a user and sensitive equipment,wherein at least one of the one or more “
hot”
component units includes one or more micro-reactors.
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-
48. An instrument for synthesis of radiolabeled compounds comprising:
-
one or more “
hot”
component units; andat least one “
cold”
component unit;wherein the one or more “
hot”
component units and the at least one “
cold”
component unit are separate units that are operatively connected to each other, and the one or more “
hot”
component units and the at least one “
cold”
component unit being positioned from each other to reduce radiation exposure to a user and sensitive equipment,wherein at least one of the one or more “
hot”
component units includes multiple reactors.
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49. An instrument for synthesis of radiolabeled compounds comprising:
-
one or more “
hot”
component units; andat least one “
cold”
component unit;wherein the one or more “
hot”
component units and the at least one “
cold”
component unit are separate units that are operatively connected to each other, and the one or more “
hot”
component units and the at least one “
cold”
component unit being positioned from each other to reduce radiation exposure to a user and sensitive equipment,wherein the instrument conducts multiple runs, that includes radiosyntheses of different products, without opening shielded enclosures.
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50. An instrument for synthesis of radiolabeled compounds comprising:
-
one or more “
hot”
component units; andat least one “
cold”
component unit;wherein the one or more “
hot”
component units and the at least one “
cold”
component unit are separate units that are operatively connected to each other, and the one or more “
hot”
component units and the at least one “
cold”
component unit being positioned from each other to reduce radiation exposure to a user and sensitive equipment,wherein the “
cold”
component unit comprises a reaction cartridge.
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51. An instillment for synthesis of radiolabeled compounds comprising:
-
one or more “
hot”
component units; andat least one “
cold”
component unit;wherein the one or more “
hot”
component units and the at least one “
cold”
component unit are separate units that are operatively connected to each other, and the one or more “
hot”
component units and the at least one “
cold”
component unit being positioned from each other to reduce radiation exposure to a user and sensitive equipment,wherein the “
cold”
component unit is located outside a mini-cell.
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Specification