Embolization

• US 8,273,324 B2
• Filed: 07/26/2011
• Issued: 09/25/2012
• Est. Priority Date: 08/30/2002
• Status: Expired due to Fees

• Current Assignee: Boston Scientific Scimed, Inc. (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed, Inc. (Boston Scientific Corporation)
• Inventors: Rioux, Robert F., Casey, Thomas V. II, Lanphere, Janel
• Primary Examiner(s): Hartley, Michael G
• Assistant Examiner(s): SAMALA, JAGADISHWAR RAO
• Application Number:
  US13/190,823
• Publication Number:
  US 20110280947A1
• Time in Patent Office: 427 Days
• Field of Search: 424/1.11, 424/129, 424/450, 424/489
• US Class Current: 424/1.11
• CPC Class Codes: A61K 41/0028 Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
• CPC Class Codes: A61K 41/0052 Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy
• CPC Class Codes: A61K 49/0452 Solutions, e.g. for injection
• CPC Class Codes: A61K 51/1244 microparticles or nanoparticles, e.g. polymeric nanoparticles
• CPC Class Codes: A61K 9/0009 involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis microelectromechanical systems A61K9/0097
• CPC Class Codes: A61K 9/1635 obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
• CPC Class Codes: A61K 9/1652 Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin homeopathic globules A61K9/1623
• CPC Class Codes: A61K 9/5094 Microcapsules containing magnetic carrier material, e.g. ferrite for drug targeting
• CPC Class Codes: A61L 24/0036 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 2430/36 for embolization or occlusion, e.g. vaso-occlusive compositions or devices
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

A particle includes a ferromagnetic material, a radiopaque material, and/or an MRI-visible material.

Claims

1. A particle, comprising a polymeric matrix and a ferromagnetic material distributed in the polymeric matrix, wherein the particle has a diameter of about 3,000 microns or less, the particle has a center region with a certain density of large pores having a mean cross-section of 20 microns or more and a surface region with a certain density of large pores, and the density of large pores of the center region is greater than the density of large pores of the surface region.

2. The particle of claim 1, wherein the ferromagnetic material is selected from the group consisting of transition metals, metal alloys, and metal oxides.

3. The particle of claim 1, wherein the ferromagnetic material is selected from the group consisting of magnetite, nickel, cobalt, iron and Mu-metal.

4. The particle of claim 1, wherein the ferromagnetic material comprises magnetite.

5. The particle of claim 1, wherein the ferromagnetic material is selected from the group consisting of soft ferrites, rare-earth magnet alloys, and amorphous and non-earth alloys.

6. The particle of claim 1, wherein the ferromagnetic material is in the shape of at least one article selected from the group consisting of particles, fibers, flakes, and powders.

7. The particle of claim 6, wherein the article has a diameter of from about two microns to about 20 microns.

8. The particle of claim 1, wherein the ferromagnetic material is substantially homogeneously distributed throughout the polymeric matrix.

9. The particle of claim 1, wherein the polymeric matrix comprises a polysaccharide.

10. The particle of claim 1, wherein the polymeric matrix comprises a member selected from the group consisting of polyvinyl alcohols, polyacrylic acids, polymethacrylic acids, poly vinyl sulfonates, carboxymethyl celluloses, hydroxyethyl celluloses, substituted celluloses, polyacrylamides, polyethylene glycols, polyamides, polyureas, polyurethanes, polyesters, polyethers, polystyrenes, polysaccharides, polylactic acids, polyethylenes, polymethylmethacrylates, polycaprolactones, polyglycolic acids, poly(lactic-co-glycolic) acids, and combinations thereof.

11. The particle of claim 1, wherein the particle further comprises a therapeutic agent.

12. The particle of claim 1, wherein the polymeric matrix comprises a first polymer and a second polymer.

13. The particle of claim 12, wherein the second polymer forms a coating over the first polymer.

14. The particle of claim 1, wherein the particle is substantially spherical.

15. The particle of claim 1, wherein the particle comprises from about 0.1 percent to about 90 percent by weight of the ferromagnetic material.

16. The particle of claim 1, wherein the polymeric matrix has a coating comprising an inorganic, ionic salt.

17. A method, comprising:

heating a plurality of particles disposed in a body lumen, wherein the particles comprise a polymeric matrix and a ferromagnetic material distributed in the polymeric matrix, the particles have a diameter of 3,000 microns or less, and the particles have a center region with a certain density of large pores having a mean cross-section of 20 microns or more and a surface region with a certain density of large pores, and the density of large pores in the center region is greater than the density of large pores of the surface region.

18. The method of claim 17, wherein the method ablates body tissue.

19. The method of claim 17, wherein heating the particles comprises exposing the particles to RF radiation.

20. The method of claim 17, wherein heating the particles heats body tissue.