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Method of isolating stem and progenitor cells from placenta

  • US 8,273,526 B2
  • Filed: 06/13/2008
  • Issued: 09/25/2012
  • Est. Priority Date: 06/18/2007
  • Status: Active Grant
First Claim
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1. A method of obtaining fetal stem and progenitor cells from a cryopreserved mammalian placenta, the method comprising:

  • a) perfusing a cryopreserved mammalian placenta with a collection solution comprising an effective amount of an agent that induces mobilization of a stem and/or progenitor cell into a blood vessel of the placenta, wherein the mobilization agent is AMD-3100, a biocompatible non-ionic surfactant, an antibody that binds specifically to an adhesion molecule and that inhibits cell adhesion, a thrombolytic enzyme, or ethylenediamine tetraacetic acid; and

    b) collecting the mobilized cells from the blood vessel, wherein the collected cells comprise fetal stem and progenitor cells.

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