Non-invasive blood constituent measuring instrument and measuring method

• US 8,275,433 B2
• Filed: 06/26/2007
• Issued: 09/25/2012
• Est. Priority Date: 03/25/2002
• Status: Expired due to Fees

• Current Assignee: Yu.Sys. Corporation
• Original Assignee: Yu.Sys. Corporation
• Inventors: Yamakoshi, Ken-ichi
• Primary Examiner(s): Winakur, Eric
• Assistant Examiner(s): Fardanesh, Marjan
• Application Number:
  US11/819,324
• Publication Number:
  US 20080027297A1
• Time in Patent Office: 1,918 Days
• Field of Search: 600309-344
• US Class Current: 600/316
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: G01N 21/359 using near infrared light
• CPC Class Codes: G01N 2201/1228 Reading time being controlled, e.g. by microprocessor
• CPC Class Codes: G01N 2201/1232 Log representation, e.g. for low transmittance
• CPC Class Codes: G01N 2201/129 Using chemometrical methods
• CPC Class Codes: G01N 33/491 by separating the blood components G01N15/05 takes precedence

Abstract

A non-invasive blood constituents measuring instrument measures blood constituent values including blood glucose concentration in a living body non-invasively. The instrument is composed of a light source 11 to irradiate a light containing plural wavelengths to a living body 13, a light receiver 14 to detect the light transmitted through a living body or reflected and scattered thereon, a spectrum analyzer 15 to analyze the light transmitted through the living body or reflected thereon at different times, a subtraction processor 18 to generate spectrum subtraction from the spectrum of the light at the different times measured by the spectrum analyzer 15, and a blood glucose concentration predictor 21 into which the output data of the subtraction processor 18 are input and which outputs a blood constituent value.

Claims

1. A non-invasive blood constituents measuring instrument comprising:

a light source for irradiating light in the near infrared range including plural wavelengths to a living body whose blood constituent concentrations are unknown;

a light receiver to detect light transmitted through the living body or reflected therefrom;

an active spectroscope for separating the light into plural wavelengths in the near infrared range at an interval of 40-50 ms period of time;

a spectrum analyzer to which the output signal of the light receiver is supplied and which analyzes spectrum of the light transmitted through the living body or reflected therefrom at different times having a shorter time intervals than a cycle time of the arterial waveform cycle;

a spectrum subtraction generator to generate a plurality of spectrum subtractions from the spectrum of the light measured by the spectrum analyzer at any two different times corresponding to time intervals of 40-50 ms; and

a blood constituent concentrations predictor into which the output data of the spectrum subtraction generator is input and which outputs the blood constituent concentrations, wherein the blood constituent concentrations predictor comprises a multi-regression analyzing model;

wherein the multi-regression analyzing model is calibrated by supplying plural sample data comprising spectrum subtractions obtained non-invasively from a living body having known blood constituent concentrations as explanatory variables and the known blood constituent concentrations as objective variables, using the non-invasive blood constituents measuring instrument;

wherein the output data of the spectrum subtraction generator obtained from the living body whose blood constituent concentrations are unknown is input to the blood constituent concentrations predictor and the blood constituent concentrations predictor outputs the blood constituent concentrations calculated by the calibrated multi-regression analyzing model.

2. A non-invasive blood constituents measuring instrument claimed in claim 1, wherein the multi-regression analyzing model is a regression analysis model using the PLS or PCR method.

3. A non-invasive blood constituent measuring instrument claimed in claim 2, wherein blood constituent concentrations of the living bodies corresponding to the sample spectrum subtractions are arranged at a specified interval within a range of concentration including a physiological concentration range.

4. A non-invasive blood constituent measuring instrument claimed in claim 1, wherein the light includes plural wavelengths in the wavelength band of 800-2400 nm arranged at an interval of 3 nm.

5. A non-invasive blood glucose concentration measuring instrument comprising:

a light source to irradiate a light in the near infrared range containing plural wavelengths to a living body whose blood glucose concentration is unknown;

a light receiver to detect the light transmitted through a living body or reflected therefrom;

an active spectroscope for separating the light into plural wavelengths in the near infrared range at an interval of 40-50 ms period of time;

a spectrum analyzer to which the output signal of the light receiver is supplied and which analyzes spectrum of the light transmitted through the living body or reflected therefrom at different times having a shorter time intervals than a cycle time of the arterial waveform;

a spectrum subtraction generator to generate a plurality of spectrum subtractions from the spectrum of the light measured by the spectrum analyzer at any two different times corresponding to time intervals of 40-50 ms; and

a blood glucose concentration predictor into which the output data of the spectrum subtraction generator is input and which outputs the blood glucose concentration, wherein the blood glucose concentration predictor comprises a multi-regression analyzing model;

wherein the multi-regression analyzing model is calibrated by supplying plural sample data comprising spectrum subtractions obtained non-invasively from a living body having known blood glucose concentrations as explanatory variables and the known blood glucose concentrations as objective variables, using the non-invasive blood glucose concentration measuring instrument; and

wherein the output data of the spectrum subtraction generator obtained from the living body whose blood glucose concentrations are unknown is input to the blood glucose concentrations predictor model and the blood glucose concentrations predictor outputs the blood glucose concentrations calculated by the calibrated multi-regression analyzing model.

6. A non-invasive blood glucose concentration measuring instrument claimed in claim 5, wherein the multi-regression analyzing model is a regression analysis model using the PLS or PCR method.

7. A non-invasive blood glucose concentration measuring instrument claimed in claim 6, wherein blood glucose concentrations according to the sample spectrum subtractions are arranged at a specified interval within a range of concentration including a physiological concentration range.

8. A non-invasive blood glucose concentration measuring instrument claimed in claim 5, wherein the light includes plural wavelengths in the wavelength band of 800-2400 nm arranged at an interval of 3 nm.

9. A method for non-invasively measuring blood constituents comprising the steps of:

irradiating a light in the near infrared range containing plural wavelengths to a living body whose blood constituents are unknown;

detecting light transmitted through or reflected from the living body and converting it into an electric signal;

separating the light into plural wavelengths in the near infrared range at an interval of 40-50 ms period of time;

analyzing spectrum of the light transmitted through the living body or reflected therefrom at different times having a shorter time intervals than a cycle time of the arterial waveform cycle using the converted electric signal;

generating a plurality of spectrum subtractions from the spectrum of the light measured by the spectrum analyzer at any two different times corresponding to time intervals of 40-50 ms; and

predicting corresponding blood constituents concentration from the spectrum subtraction;

wherein the step of predicting the blood constituents concentration further comprises;

preparing a multi-regression analyzing mode;

calibrating the multi-regression analyzing model by supplying plural sample data comprising spectrum subtractions obtained non-invasively from a living body having known blood constituent concentrations as explanatory variables and the known blood constituent concentrations as objective variables, using the non-invasive blood constituents measuring instrument;

inputting the output data of the spectrum subtraction generator obtained from the living body whose blood constituents are unknown to the blood constituent concentrations predictor; and

outputting the blood constituent concentrations calculated by the calibrated multi-regression analyzing model in the blood constituent concentrations predictor.

10. A method for non-invasively measuring blood constituents claimed in claim 9, wherein the multi-regression analyzing model is constructed using the PLS or PCR method.

11. A method for non-invasively measuring blood constituents claimed in claim 9, wherein the light includes plural wavelengths in the wavelength band of 800-2400 nm arranged at an interval of 3 nm.

12. A method for non-invasively measuring blood glucose concentration comprising the steps of:

irradiating a light in the near infrared range containing plural wavelengths to a living body whose blood glucose concentration is unknown;

detecting light transmitted through or reflected from the living body and converting it into an electric signal;

separating the light into plural wavelengths in the near infrared range at an interval of 40-50 ms period of time;

analyzing spectrum of the light transmitted through the living body or reflected therefrom at different times having a shorter time intervals than a cycle time of the arterial waveform cycle using the converted electric signal;

generating a plurality of spectrum subtractions from the spectrum of the light measured by the spectrum analyzer at any two different times corresponding to time intervals of 40-50 ms; and

predicting corresponding blood glucose concentration from the spectrum subtraction;

wherein the step of predicting the blood glucose concentration further comprises;

preparing a multi-regression analyzing model;

calibrating the multi-regression analyzing model by supplying plural sample data comprising spectrum subtractions obtained non-invasively from a living body having known blood glucose concentrations as explanatory variables and the known blood glucose concentrations as objective variable using a non-invasive blood glucose measuring instrument;

inputting the output data of the spectrum subtraction generator obtained from the living body whose blood glucose concentrations are is unknown to the blood glucose concentrations predictor; and

outputting the blood glucose concentrations calculated by the calibrated multi-regression analyzing model in the blood glucose concentrations predictor.

13. A method for non-invasively measuring blood glucose concentrations claimed in claim 12, wherein the multi-regression analyzing model is constructed using the PLS or PCR method.

14. A method for non-invasively measuring blood glucose concentrations claimed in claim 12, wherein the light includes plural wavelengths in the wavelength band of 800-2400 nm arranged at an interval of 3 nm.