Method and apparatus for non-invasive fetal oximetry

• US 8,275,436 B2
• Filed: 03/02/2010
• Issued: 09/25/2012
• Est. Priority Date: 03/02/2010
• Status: Active Grant

• Current Assignee: Beijing Weitexing Technology Co., Ltd.
• Original Assignee: Wen Huang, Yixiang Wang
• Inventors: Wang, Yixiang, Huang, Wen
• Primary Examiner(s): Laballe, Clayton E
• Assistant Examiner(s): Hancock, Dennis
• Application Number:
  US12/715,974
• Publication Number:
  US 20110218413A1
• Time in Patent Office: 938 Days
• Field of Search: 600/324, 600/338
• US Class Current: 600/324
• CPC Class Codes: A61B 5/02411 of foetuses
• CPC Class Codes: A61B 5/1464 specially adapted for foetal tissue
• CPC Class Codes: A61B 5/344 Foetal cardiography
• CPC Class Codes: A61B 5/4356 Assessing uterine contractions A61B5/033 takes precedence
• CPC Class Codes: A61B 5/4362 Assessing foetal parameters
• CPC Class Codes: A61B 5/6823 Trunk, e.g., chest, back, abdomen, hip
• CPC Class Codes: A61B 5/7257 using Fourier transforms
• CPC Class Codes: A61B 8/02 Measuring pulse or heart rate
• CPC Class Codes: A61B 8/0866 involving foetal diagnosis; pre-natal or peri-natal diagnosis of the baby

Abstract

Method and apparatus to non-invasively measure fetal blood oxygen saturation levels. Optical sensors capable of producing and detecting multiple wavelengths of tissue penetrating light are placed on the surface of the maternal abdomen, and the light beams directed to pass through at least a portion of the uterus containing the fetus. The fetal heart rate is monitored by Doppler ultrasound, and pure maternal optical signal related to maternal arterial blood flow are also measured. The optical sensors collect composite signals containing both maternal and fetal hemoglobin absorption spectral data and modulated by their respective pulsatile blood flows. The composite signals processed in the time domain and frequency domain, the pure maternal pulsatile optical signal used to extract the maternal contribution to the composite signal, and the fetal pulsatile signal is used to lock onto and extract the fetal contribution to the composite signal, and a fetal blood oxygen level deduced.

Claims

1. A method of non-invasively determining fetal blood oxygen saturation levels, comprising:

sending a plurality of tissue penetrating light beams from a plurality of different wavelength optical light sources through a portion of the maternal body and a portion of the fetus, and detecting the resulting transmitted or reflected light beams, thus obtaining composite time varying maternal and time varying fetal optical signals related to maternal and fetal arterial blood flows;

detecting the fetal heartbeat;

detecting the pure time varying maternal optical signals related to maternal arterial blood flows and/or maternal heartbeat;

using said pure time varying maternal optical signals and/or maternal heartbeat to reduce the maternal portion of said composite time varying maternal and time varying fetal optical signal;

using said fetal heartbeat to detect and enhance said time varying fetal optical signal

and using said time varying fetal optical signal to compute a fetal blood oxygen saturation level.

2. The method of claim 1, in which said different wavelengths comprise tissue penetrating two or more wavelengths between 620 nm and 1,200 nm.

3. The method of claim 1, wherein said fetal heartbeat is detected using a Doppler ultrasound device, fetal stethoscope, or other method.

4. The method of claim 1, wherein said maternal heartbeat is detected from the pure time varying maternal optical signals related to maternal arterial blood flow, or by maternal ECG R-wave electrodes, or other method.

5. The method of claim 1, wherein at least one light emitting device to produce said plurality of tissue penetrating light beams, and at least one light detecting device to detect said resulting transmitted or reflected light beams are located on a belt or other holder device and placed on the skin of the maternal abdomen.

6. The method of claim 1, wherein said pure time varying maternal blood optical signal is obtained by an optical sensor positioned to pass light beams through a portion of said maternal body that does not intersect the fetus.

7. The method of claim 6, wherein said pure time varying maternal optical signal is obtained by an optical sensor positioned on a maternal finger or other part of said maternal body.

8. The method of claim 1, further transforming said pure time varying maternal optical signal and time varying fetal optical signal into the frequency domain by a first transform;

reducing said maternal portion of said composite time varying maternal and time varying fetal spectral data in said frequency domain;

and detecting and enhancing said time varying fetal spectral data in said frequency domain.

9. The method of claim 8, wherein said first transform is selected from the group consisting of FFT transforms or Z-transforms.

10. The method of claim 1, wherein said time varying fetal spectral data is analyzed for the characteristic optical absorption characteristics of fetal hemoglobin.

11. A method of non-invasively determining fetal blood oxygen saturation levels, comprising:

sending a plurality of tissue penetrating light beams from a plurality of different wavelength optical light sources through a portion of the maternal body and a portion of the fetus, and detecting the resulting transmitted or reflected light beams, thus obtaining composite maternal and fetal optical signals related to maternal and fetal arterial blood flows;

wherein at least one light emitting device to produce said plurality of tissue penetrating light beams, and at least one light detecting device to detect said resulting transmitted or reflected light beams are located on a belt or other holder device and placed on the skin of the maternal abdomen;

detecting the fetal heartbeat using a Doppler ultrasound device, fetal stethoscope, or other method;

detecting pure maternal blood optical data using an optical sensor positioned to pass light beams through a portion of said maternal body that does not intersect the fetus;

detecting the maternal heartbeat from the time varying maternal optical signals related to maternal arterial blood flow, or using maternal ECG R-wave electrodes, or other method;

using said pure maternal blood optical data or said maternal heartbeat data to reduce the maternal portion of said composite maternal and fetal optical signals;

using said fetal heartbeat to detect and enhance the said fetal portion of said composite maternal and fetal optical signals producing an enhanced fetal optical signal;

and using said enhanced fetal optical signal to compute a fetal blood oxygen saturation level.

12. The method of claim 11, further transforming said composite maternal and fetal optical signals into the frequency domain by a first transform producing frequency transformed composite maternal and fetal optical signals;

reducing said maternal portion of said frequency transformed maternal and fetal optical signals in said frequency domain;

and detecting and enhancing said the fetal component of said frequency transformed maternal and fetal optical signals in said frequency domain.

13. The method of claim 12, wherein said first transform is selected from the group consisting of FFT transforms or Z-transforms or other transform method.

14. The method of claim 12, further processing said frequency transformed composite time maternal and fetal optical signals back from the frequency domain into the time domain using an inverse FFT transform or inverse Z-transform or other inverse transform method.

15. A pulse oximeter device for non-invasively determining fetal blood oxygen saturation levels, comprising:

a plurality of optical light sources capable of producing a plurality of tissue penetrating light beams at a plurality of different wavelengths;

at least one photodetector capable of detecting said plurality of tissue penetrating light beams after said light beams pass through tissue;

said plurality of optical light sources and at least one photodetector positioned so as to send light beams through portions of both the maternal body and a portion of the body of a fetus, producing a set of composite maternal and fetal optical signals;

at least one fetal heartbeat sensor producing fetal heartbeat data;

at least one optical sensor producing pure maternal optical data, said maternal optical sensor operating on a portion of said maternal body that does not intersect the fetus;

and/or one maternal heartbeat sensor producing maternal heartbeat data;

at least one processor capable of taking said composite maternal and fetal optical signal data, said pure maternal optical signal data and/or said maternal heartbeat data, processing said data in the time domain and frequency domain, reducing the maternal contribution to said composite maternal and fetal optical signal data, enhancing said fetal optical signal data, and calculating a fetal blood oxygen saturation value from said amplified fetal optical signal data.

16. The device of claim 15, wherein at least some of said plurality of light sources and at least one photodetector are located on a belt or other holder device and placed on the skin of the maternal abdomen.

17. The device of claim 15, wherein at least some of said plurality of light sources, at least one photodetector, said fetal heartbeat sensor, and at least one maternal heartbeat sensor are located on a belt or other holder device and placed on the skin of the maternal abdomen.

18. The device of claim 15, in which said fetal heartbeat sensor is a Doppler ultrasound sensor, fetal stethoscope, or other fetal heartbeat detector.

19. The device of claim 15, in which said maternal heartbeat sensor comprises ECG R-wave electrodes or other heartbeat detector.