Device for delivering medicament

• US 8,276,583 B2
• Filed: 01/08/2008
• Issued: 10/02/2012
• Est. Priority Date: 01/17/2007
• Status: Active Grant

• Current Assignee: Shl Medical AG
• Original Assignee: SHL Group AB
• Inventors: Farieta, Antonio, Kronestedt, Victor
• Primary Examiner(s): CROW, STEPHEN R
• Application Number:
  US12/516,933
• Publication Number:
  US 20100065049A1
• Time in Patent Office: 1,729 Days
• Field of Search: 128/203.15, 604/298, 604/311, 604/82
• US Class Current: 128/203.15
• CPC Class Codes: A61M 11/007 Syringe-type or piston-type sprayers or atomisers
• CPC Class Codes: A61M 11/08 Pocket atomisers of the injector type aerosol cans A61M15/009
• CPC Class Codes: A61M 15/08 Inhaling devices inserted into the nose
• CPC Class Codes: A61M 2005/2013 triggering of discharging means by contact of injector with patient body
• CPC Class Codes: A61M 2005/31598 having multiple telescopically sliding coaxial pistons encompassing volumes for components to be mixed
• CPC Class Codes: A61M 2205/215 Tilt detection, e.g. for warning or shut-off
• CPC Class Codes: A61M 2210/0612 Eyes
• CPC Class Codes: A61M 2210/0618 Nose
• CPC Class Codes: A61M 2210/0625 Mouth
• CPC Class Codes: A61M 5/2033 Spring-loaded one-shot injectors with or without automatic needle insertion multishot dosing syringes A61M5/31525, needle insertion only A61M5/3287
• CPC Class Codes: A61M 5/2066 comprising means for injection of two or more media, e.g. by mixing
• CPC Class Codes: A61M 5/2448 comprising means for injection of two or more media, e.g. by mixing
• CPC Class Codes: A61M 5/3146 Priming, e.g. purging, reducing backlash or clearance
• CPC Class Codes: A61M 5/31535 Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
• CPC Class Codes: A61M 5/31553 without axial movement of dose setting member
• CPC Class Codes: A61M 5/31561 using freely adjustable volume steps
• CPC Class Codes: A61M 5/31566 Means improving security or handling thereof
• CPC Class Codes: A61M 5/31578 based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
• CPC Class Codes: A61M 5/31583 based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
• CPC Class Codes: A61M 5/31591 Single dose, i.e. individually set dose administered only once from the same medicament reservoir, e.g. including single stroke limiting means
• CPC Class Codes: A61M 5/326 : Fully automatic sleeve extension, i.e. in which triggering of the sleeve does not require a deliberate action by the user

Abstract

The present invention relates to a device for delivery of medicament comprising a main housing; a container arranged in said housing and arranged to be connected to a medicament delivery member, wherein said container includes at least two chambers and at least one longitudinally movable plunger and wherein at least one chamber contains a medicament agent; a pre-treating arrangement acting on said container; drive force means acting on a longitudinally movable plunger rod capable of exerting a force on said container; and activating delivery means acting a said drive force means for delivering medicament via said medicament delivery member characterised in that said pre-treating arrangement comprises clickable means for manually and delay intermittently mixing said medicament agent and for manually priming said container.

Claims

1. A device for delivery of medicament, comprising:

a main housing;

a multi-chamber container, comprising a first chamber containing a diluent, a second chamber containing a medicament agent, a bypass channel, an outlet provided with a mechanism to be connected to a medicament delivery member, and at least one longitudinally movable plunger;

a pre-treating arrangement acting on at least one longitudinally movable plunger for mixing the medicament agent with the diluent and obtaining a mixed medicament;

a drive force mechanism configured to act on a longitudinally movable plunger rod capable of exerting a force on the container for delivering the mixed medicament; and

an activating delivery mechanism configured to act on the drive force mechanism for initiating the delivering of medicament via the medicament delivery member;

wherein the pre-treating arrangement comprises a clickable mechanism resiliently and operably connected to a longitudinally movable second rod that is partially and slidably arranged inside the longitudinally movable plunger rod such that the clickable mechanism is adapted to be manually and intermittently activated for stepwise pushing the second rod inside the container and thereby mixing the medicament agent with the diluent.

2. The device of claim 1, wherein the clickable mechanism comprises a pre-treating sleeve and a resilient device, and the pre-treating sleeve is adapted to be manually activated from a non-depressed position to a depressed position against a counteracting force from the resilient device such that when the pre-treating sleeve is activated from the non-depressed position to the depressed position, the second rod is pushed one step inside the container and the pre-treating sleeve is restored to its non-depressed position.

3. The device of claim 2, wherein the pre-treating sleeve comprises inwardly flexible tongues arranged to interact with a ratchet having a predetermined number of steps arranged on the longitudinally movable second rod, and a last step of the ratchet is arranged for priming the container.

4. The device of claim 1, wherein the clickable mechanism comprises a delay device arranged around the clickable mechanism and configured to delay intermittent pushing of the second rod.

5. The device of claim 1, wherein the pre-treating arrangement further comprises a blocking mechanism that is operably interconnected to the clickable mechanism and that permits activation of the clickable mechanism only when the device is substantially vertical with the medicament delivery member in a specific direction.

6. The device of claim 5, wherein for an injection device, the medicament delivery member is directed upward.

7. The device of claims 5, wherein the blocking mechanism comprises a cylindrical sleeve, a cylindrical wall arranged on an inner surface of the main housing, and an obstruction device;

and inner surfaces of the blocking mechanism are arranged to interact with the clickable mechanism.

8. The device of claim 7, wherein when the device is held substantially vertical, the obstruction device is an intermediate in an interaction between the blocking mechanism and the pre-treating sleeve.

9. The device of claim 1, further comprising a dose setting mechanism that is arranged to interact with the drive force mechanism and that sets a predetermined dose to be delivered.

10. The device of claim 1, wherein the activating delivery mechanism is configured to extend around the medicament delivery member upon withdrawal of the device from a delivery site.

11. The device of claim 10, wherein for injection devices, the activating delivery mechanism is configured to lockingly cover the needle after use.

12. The device of claim 1, wherein the medicament delivery member is configured as a mouth piece or a nasal piece.

13. The device of claim 1, wherein the medicament delivery member is configured as a nozzle, whereby the predetermined dose of medicament is sprayed into an eye or onto a skin of a patient.

14. The device of claim 1, wherein the medicament delivery member is configured as a member that introduces the predetermined dose of medicament to an eye of a patient as at least one drop.

15. The device of claim 1, wherein the medicament delivery member is configured as a needle for injection of the predetermined dose of medicament into a body of a patient.