Implantable device for controlled, extended delivery of parathyroid hormone
First Claim
1. An implantable device for controlled delivery of parathyroid hormone to a patient in need thereof comprising:
- a substrate having a plurality of discrete reservoirs;
a quantity of parathyroid hormone contained in each of the reservoirs;
a plurality of reservoir caps separating said quantity of parathyroid hormone from an environment outside of the reservoirs, and preventing the parathyroid hormone from being released from the implantable device; and
an electrical input lead and an output lead, which leads are continuous with, or connected by an intermetallic junction to, each of the reservoir caps and configured to pass an electric current from a power source through said each reservoir cap and thereby cause the reservoir cap to rupture by electrothermal ablation and permit the parathyroid hormone to be released from the implantable device,wherein each of said reservoir caps comprises a multi-layer metal structure.
1 Assignment
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Accused Products
Abstract
Method and devices are provided for extended and controlled delivery of parathyroid hormone to a patient. The method includes implanting a medical device into the patient, the medical device comprising a substrate, a plurality of reservoirs in the substrate, a release system contained in each of the reservoirs, wherein the release system comprises parathyroid hormone; and controllably releasing a pharmaceutically effective amount of the parathyroid hormone from the reservoirs. The parathyroid hormone can be released intermittently, such as once daily over an extended period (e.g., two months, ten months, or more.). The device can further include reservoirs containing a bone resorption inhibitor or other drug for release. The devices are useful in delivering PTH for the treatment and prevention of bone loss, such as associated with osteoporosis.
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Citations
8 Claims
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1. An implantable device for controlled delivery of parathyroid hormone to a patient in need thereof comprising:
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a substrate having a plurality of discrete reservoirs; a quantity of parathyroid hormone contained in each of the reservoirs; a plurality of reservoir caps separating said quantity of parathyroid hormone from an environment outside of the reservoirs, and preventing the parathyroid hormone from being released from the implantable device; and an electrical input lead and an output lead, which leads are continuous with, or connected by an intermetallic junction to, each of the reservoir caps and configured to pass an electric current from a power source through said each reservoir cap and thereby cause the reservoir cap to rupture by electrothermal ablation and permit the parathyroid hormone to be released from the implantable device, wherein each of said reservoir caps comprises a multi-layer metal structure. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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Specification