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Implantable device for controlled, extended delivery of parathyroid hormone

  • US 8,277,440 B2
  • Filed: 01/23/2009
  • Issued: 10/02/2012
  • Est. Priority Date: 09/04/2002
  • Status: Expired due to Fees
First Claim
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1. An implantable device for controlled delivery of parathyroid hormone to a patient in need thereof comprising:

  • a substrate having a plurality of discrete reservoirs;

    a quantity of parathyroid hormone contained in each of the reservoirs;

    a plurality of reservoir caps separating said quantity of parathyroid hormone from an environment outside of the reservoirs, and preventing the parathyroid hormone from being released from the implantable device; and

    an electrical input lead and an output lead, which leads are continuous with, or connected by an intermetallic junction to, each of the reservoir caps and configured to pass an electric current from a power source through said each reservoir cap and thereby cause the reservoir cap to rupture by electrothermal ablation and permit the parathyroid hormone to be released from the implantable device,wherein each of said reservoir caps comprises a multi-layer metal structure.

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