Treatment of atrial fibrillation by overlapping curvilinear lesions

• US 8,277,444 B2
• Filed: 08/15/2006
• Issued: 10/02/2012
• Est. Priority Date: 09/09/1994
• Status: Expired due to Fees

• Current Assignee: Cardiofocus Incorporated
• Original Assignee: Cardiofocus Incorporated
• Inventors: Arnold, Jeffrey M., Sinofsky, Edward L., Baxter, Lincoln S., Farr, Norman E.
• Primary Examiner(s): ROANE, AARON F
• Application Number:
  US11/504,354
• Publication Number:
  US 20070078451A1
• Time in Patent Office: 2,240 Days
• Field of Search: 606 2- 16, 606/32, 606/41, 607 88- 94, 128/898
• US Class Current: 606/41
• CPC Class Codes: A61B 18/24 with a catheter A61B18/26, A61B18/28 take precedence
• CPC Class Codes: A61B 18/245 for removing obstructions in blood vessels or calculi
• CPC Class Codes: A61B 2017/00057 Light
• CPC Class Codes: A61B 2017/00061 spectrum
• CPC Class Codes: A61B 2018/0097 Cleaning probe surfaces
• CPC Class Codes: A61B 2018/2261 with scattering, diffusion or dispersion of light
• CPC Class Codes: A61B 2018/2266 with a lens, e.g. ball tipped
• CPC Class Codes: A61B 2018/2272 with reflective or refractive surfaces for deflecting the beam A61B2018/2261, A61B2018/2266 take precedence
• CPC Class Codes: A61B 2090/065 for measuring contact or contact pressure
• CPC Class Codes: A61L 2/10 Ultraviolet radiation
• CPC Class Codes: A61L 29/085 Macromolecular materials
• CPC Class Codes: A61N 7/02 Localised ultrasound hyperthermia hyperthermia in general A61F7/00
• CPC Class Codes: C08L 27/12 containing fluorine atoms

Abstract

Ablation methods and instruments are disclosed for creating lesions in tissue, especially cardiac tissue for treatment of arrhythmias and the like. Percutaneous ablation instruments in the form of coaxial catheter bodies are disclosed having at least one central lumen therein and having one or more balloon structures at the distal end region of the instrument. The instruments include an energy emitting element which is independently positionable within the lumen of the instrument and adapted to project radiant energy through a transmissive region of a projection balloon to a target tissue site to form a series of lesions on the target tissue.

Claims

1. A method of treating atrial fibrillation, comprising:

seating a distal portion of a cardiac ablation instrument against tissue at a location within a patient'"'"'s heart adjacent an ostium of a pulmonary vein, the instrument having a catheter body with at least one lumen therein and an energy emitting element independently positionable along a longitudinal axis within the at least one lumen of the catheter body, wherein the instrument further includes an inflatable projection balloon that surrounds the energy emitting element and defines the distal portion that is seated at the target location, the instrument having a wave guide disposed at the distal end of the energy emitting element;

positioning the energy emitting element at a first position relative to the catheter body moving the energy emitting element along the longitudinal axis to a first location;

activating the energy emitting element to project ablative energy to form a first partially circumferential lesion in a proximity of the ostium of the pulmonary vein, the energy emitting element and projection balloon being constructed such that ablative energy is projected from the energy emitting element directly to a transmissive region of the projection balloon that is in contact the tissue at the target location and permits the ablative energy to pass therethrough, the ablative energy contacting the projection balloon in the transmissive region thereof;

repositioning the energy emitting element at a second position relative to the catheter body by moving the energy emitting element along the longitudinal axis to a second location, the distal portion of the instrument remaining seated at said location;

activating the energy emitting element to project ablative energy to form at least a second partially circumferential lesion in the proximity of the ostium of the pulmonary vein by projecting the ablative energy from the energy emitting element through the wave guide in a distal direction and at an acute angle relative to the longitudinal axis to the transmissive region of the projection balloon that permits passage of the ablative energy therethrough, the ablative energy contacting the projection balloon in the transmissive region thereof, the second partially circumferential lesion being axially combined with the first partially circumferential lesion and overlapping the first partially circumferential lesion at least one location, the distal portion of the instrument remaining seated at said location; and

continuing the steps of repositioning the energy emitter along the longitudinal axis and activating until an axially combined lesion is formed that encircles the pulmonary vein.

2. The method of claim 1, wherein each lesion is in the shape of an arc.

3. The method of claim 1, wherein each lesion has a similar thickness.

4. The method of claim 1, further comprising adjusting the position of the energy emitting element such that the at least second lesion has a different thickness than the first lesion.

5. The method of claim 1, further comprising inflating a projection balloon to clear blood from a transmission pathway between the energy emitting element and a target region of cardiac tissue.

6. The method of claim 5, further comprising determining whether a clear transmission path exists between the energy emitting element and the target region based on reflectance measurements by an optical sensor disposed within the ablation instrument.

7. The method of claim 6, further comprising measuring at least two different wavelengths of reflected light collected by the optical sensor to determine whether a projection path has been established.

8. The method of claim 1, wherein the step of activating the energy emitting element further comprises activating a beam-forming optical waveguide to expose the target region to an annular beam of light energy to induce the combined lesion in cardiac tissue.

9. The method of claim 1, wherein the step of activating the energy emitting element further comprises activating a light emitting element to expose the target region to light energy to induce photocoagulation of cardiac tissue within the target region.

10. The method of claim 1, wherein the step of activating the energy emitting element further comprises activating a light emitting element to expose the target region to light energy to induce the combined lesion in the cardiac tissue.

11. The method of claim 1, wherein the step of activating the energy emitting element further comprises generating photoablative radiation at a wavelength in the range of about 800 nm to 1000 nm.

12. The method of claim 1, wherein the step of activating the energy emitting element further comprises generating photoablative radiation at a wavelength in the range of about 915 nm to 980 nm.