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Methods and apparatus for centrifugal liquid chromatography

  • US 8,277,651 B2
  • Filed: 03/12/2010
  • Issued: 10/02/2012
  • Est. Priority Date: 03/13/2009
  • Status: Active Grant
First Claim
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1. A chromatographic system comprising:

  • a rotor configured to rotate about an axis, said rotor comprising;

    an enclosed flow path configured to contain a fluid under pressure including

         1) a first segment for receiving the fluid from an entrance to the flow path and communicating the fluid away from the axis and

         2) a second segment in fluid communication with the first segment for communicating the fluid toward the axis and out an exit to the flow path, said exit located at a first radial distance from the axis, such that during a rotation of the rotor the fluid continually drains from the exit when a fluid level in the first segment is located at a second radial distance from the axis less than the first radial distance; and

    a chromatographic enclosure, carried on the rotor, located between the entrance and the exit of the fluid conduit, said chromatographic enclosure being arranged to contain an associated chromatographic stationary phase and to facilitate transmission of a fluid through the chromatographic stationary phase contained within the chromatographic enclosure, wherein the fluid is driven through the chromatographic stationary phase via centrifugal force generated from the rotation of the rotor.

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