Implantable analyte sensor
First Claim
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1. A method for forming a membrane for use with an implantable electrochemical glucose sensor, the method comprising:
- forming a membrane configured to provide in vivo an interface between an implantable electrochemical glucose sensor and a biological fluid, wherein forming the membrane comprises forming a domain configured to substantially reduce a flux of potentially electrochemically interfering substances through the membrane and control diffusion of glucose and oxygen through the membrane, wherein forming a domain comprises;
forming a sufficiently diluted solvent solution comprising a solvent and a polymer blend of a silicone-containing polyurethane polymer and a hydrophilic polymer, wherein the sufficiently diluted solvent solution comprises a ratio of polymer blend to solvent of about 1 to 10 wt. % polymer blend to about 90 to 99 wt. % solvent; and
applying the solvent solution to a surface at a speed sufficient to substantially avoid film thickness inhomogeneities due to evaporation of the sufficiently diluted solvent solution.
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Abstract
An implantable analyte sensor including a sensing region for measuring the analyte and a non-sensing region for immobilizing the sensor body in the host. The sensor is implanted in a precisely dimensioned pocket to stabilize the analyte sensor in vivo and enable measurement of the concentration of the analyte in the host before and after formation of a foreign body capsule around the sensor. The sensor further provides a transmitter for RF transmission through the sensor body, electronic circuitry, and a power source optimized for long-term use in the miniaturized sensor body.
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9 Claims
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1. A method for forming a membrane for use with an implantable electrochemical glucose sensor, the method comprising:
forming a membrane configured to provide in vivo an interface between an implantable electrochemical glucose sensor and a biological fluid, wherein forming the membrane comprises forming a domain configured to substantially reduce a flux of potentially electrochemically interfering substances through the membrane and control diffusion of glucose and oxygen through the membrane, wherein forming a domain comprises; forming a sufficiently diluted solvent solution comprising a solvent and a polymer blend of a silicone-containing polyurethane polymer and a hydrophilic polymer, wherein the sufficiently diluted solvent solution comprises a ratio of polymer blend to solvent of about 1 to 10 wt. % polymer blend to about 90 to 99 wt. % solvent; and applying the solvent solution to a surface at a speed sufficient to substantially avoid film thickness inhomogeneities due to evaporation of the sufficiently diluted solvent solution. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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