Compositions for delivery of therapeutics and other materials
First Claim
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1. A method of delivering an active agent to a target site comprising administering a composition to a subject, the composition comprising:
- a first molecule comprising;
a first hydrophobic group comprising a first metal binding domain (FMBD);
a metal ion chelated to the FMBD; and
an active agent comprising a second MBD (SMBD) coordinately bonded to said metal ion; and
a second molecule comprising;
a second hydrophobic group; and
a first hydrophilic group covalently linked to the second hydrophobic group;
wherein after administration of the composition to said subject, the active agent is released in a sustained manner.
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Abstract
This disclosure relates to compositions for delivering agents to a subject, and in particular, to compositions for delivery of therapeutic agents or diagnostic agents in the presence or absence of targeting moieties. In part, this disclosure relates to compositions comprising a hydrophobic group with a first end and a second end, a first metal binding domain linked to the hydrophobic group, a metal ion capable of being chelated to the first metal binding domain, and an agent linked to a second metal binding domain capable of chelating to the metal ion.
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Citations
22 Claims
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1. A method of delivering an active agent to a target site comprising administering a composition to a subject, the composition comprising:
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a first molecule comprising; a first hydrophobic group comprising a first metal binding domain (FMBD); a metal ion chelated to the FMBD; and an active agent comprising a second MBD (SMBD) coordinately bonded to said metal ion; and a second molecule comprising; a second hydrophobic group; and a first hydrophilic group covalently linked to the second hydrophobic group; wherein after administration of the composition to said subject, the active agent is released in a sustained manner. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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Specification