Methods of view selection for radioactive emission measurements
First Claim
1. A method for selecting a set of optimal views of a volume to be imaged by radioactive-emission, after an administration of a radiopharmaceutical, the method comprising:
- providing the volume to be imaged;
providing a collection of views of the volume to be imaged, each said view is associated with at least one viewing parameter selected from a group consisting of a detector location, a detector orientation, a viewing angle, a detector material, a detector thickness, a collimator length, a septa thickness, a cell size, a detection duration, a time of detection, and a type of the radiopharmaceutical;
providing a scoring function, by which any set of at least one view from the collection is scorable with a score that rates information obtained from the volume by the set;
forming sets of views and scoring them, by the scoring function;
selecting a set of views from the collection, based on the scoring function; and
instructing a three dimensional (3D) reconstruction of an intensity distribution in at least some of the volume from radioactive-emission measurements of said selected set of views.
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Abstract
A method is described for identifying an optimal, or preferred set of views for radioactive-emission measurements of a body structure, based on modeling the body structure, in terms of its geometry and radioactive emission distribution, obtaining different sets of views of the model, and scoring the different sets of views, with a scoring function, using information theoretic measures, for example, for uniformity, reliability and separability in reconstruction.
The preferred set of views may then be applied in imaging the in-vivo body structure, that has been modeled.
277 Citations
24 Claims
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1. A method for selecting a set of optimal views of a volume to be imaged by radioactive-emission, after an administration of a radiopharmaceutical, the method comprising:
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providing the volume to be imaged; providing a collection of views of the volume to be imaged, each said view is associated with at least one viewing parameter selected from a group consisting of a detector location, a detector orientation, a viewing angle, a detector material, a detector thickness, a collimator length, a septa thickness, a cell size, a detection duration, a time of detection, and a type of the radiopharmaceutical; providing a scoring function, by which any set of at least one view from the collection is scorable with a score that rates information obtained from the volume by the set; forming sets of views and scoring them, by the scoring function; selecting a set of views from the collection, based on the scoring function; and instructing a three dimensional (3D) reconstruction of an intensity distribution in at least some of the volume from radioactive-emission measurements of said selected set of views. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A method for selecting a set of optimal views of a volume to be imaged by radioactive-emission, after an administration of a radiopharmaceutical, the method comprising:
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providing the volume to be imaged; providing at least one emittance model; providing a collection of views of the volume to be imaged; providing a scoring function, by which any set of at least one view from the collection is scorable with a score that rates information obtained from the volume by the set; forming sets of views and scoring them, by the scoring function; and selecting a set of views from the collection, based on the scoring function; wherein an emittance model comprises a representation of a radioactive-emission density distribution of the volume, wherein; the providing at least one emittance model comprises providing a plurality of emittance models of substantially identical volumes, but different radioactive-emission density distributions, the forming sets of views from the collection of views and scoring them, comprises forming substantially identical sets of views for all the models and scoring the sets with respect to each model, based on the information theoretic measure of reliability; and the selecting one of the sets of views, based on its score, comprises selecting based on the average score for the plurality of models.
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19. A method for selecting a set of optimal views of a volume to be imaged by radioactive-emission, after an administration of a radiopharmaceutical, the method comprising:
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providing the volume to be imaged; providing at least one emittance model; providing a collection of views of the volume to be imaged; providing a scoring function, by which any set of at least one view from the collection is scorable with a score that rates information obtained from the volume by the set; forming sets of views and scoring them, by the scoring function; and selecting a set of views from the collection, based on the scoring function; wherein an emittance model comprises a representation of a radioactive-emission density distribution of the volume, wherein; the providing at least one emittance model comprises providing a plurality of pairs of models of substantially identical volumes, but different radioactive-emission density distributions, wherein the difference between the radioactive-emission density distributions for each pair is defined by at least one delta; the scoring function is based on an information theoretic measure of separability; the forming the sets of views from the collection of views and scoring them, comprises forming substantially identical sets of views for the plurality of pairs of models and scoring the sets with respect to each of the pairs; and the selecting one of the sets of views, based on its score, comprises selecting based on an average score for the plurality of pairs.
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20. A method for selecting a set of optimal views of a volume to be imaged by radioactive-emission, after an administration of a radiopharmaceutical, the method comprising:
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providing the volume to be imaged; providing at least one emittance model; providing a collection of views of the volume to be imaged; providing a scoring function, by which any set of at least one view from the collection is scorable with a score that rates information obtained from the volume by the set; forming sets of views and scoring them, by the scoring function; and selecting a set of views from the collection, based on the scoring function; wherein an emittance model comprises a representation of a radioactive-emission density distribution of the volume, wherein; the providing the at least one emittance model includes providing a first and a second emittance models of different radiation emission density distributions and a third emittance model of no radiation emission density distribution; and the providing the scoring function comprises providing a scoring function as a combination of uniformity, separability and reliability.
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21. A method for selecting a set of optimal views of a volume to be imaged by radioactive-emission, after an administration of a radiopharmaceutical, the method comprising:
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providing the volume to be imaged; providing a collection of views of the volume to be imaged; providing a scoring function, by which any set of at least one view from the collection is scorable with a score that rates information obtained from the volume by the set; forming sets of views and scoring them, by the scoring function; and selecting a set of views from the collection, based on the scoring function; wherein the selecting comprises; initially establishing a current set of views from the collection of views; and iteratively expanding the current set until a predefined number of views are obtained, wherein a set expansion iteration comprises; forming a respective expanded set for each view not in the current set, wherein an expanded set comprises the current set and a respective view; calculating a respective score for each of the expanded sets using the scoring function; and equating the current set equal to a highest-scoring expanded set. - View Dependent Claims (22)
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23. A non-transitory computer-readable storage medium containing a set of instructions for selecting a set of optimal views of a volume to be imaged by radioactive-emission, after an administration of a radiopharmaceutical, the set of instructions comprising:
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a volume provision routine for providing the volume to be imaged; a view provision routine for providing a collection of views of the volume to be imaged, each said view is associated with at least one viewing parameter selected from a group consisting of a detector location, a detector orientation, a viewing angle, a detector material, a detector thickness, a collimator length, a septa thickness, a cell size, a detection duration, a time of detection, and a type of the radiopharmaceutical; a scoring function provision routine for providing a scoring function, by which any set of at least one view from the collection is scorable with a score that rates information obtained from the volume by the set; a set formation routine, for forming sets of views and scoring them, by the scoring function; and a set selection routine selecting a set from the collection, based on the scoring function; wherein said set is used for instructing a three dimensional (3D) reconstruction of an intensity distribution in at least some of the volume from radioactive-emission measurements of said selected set of views.
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24. A computer system, configured for selecting a set of optimal views of a volume to be imaged by radioactive-emission, after an administration of a radiopharmaceutical, comprising:
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a volume provision routine for providing the volume to be imaged; a view provision routine for providing a collection of views of the volume to be imaged, each said view is associated with at least one viewing parameter selected from a group consisting of a detector location, a detector orientation, a viewing angle, a detector material, a detector thickness, a collimator length, a septa thickness, a cell size, a detection duration, a time of detection, and a type of the radiopharmaceutical; a scoring function provision routine for providing a scoring function, by which any set of at least one view from the collection is scorable with a score that rates information obtained from the volume by the set; a set formation routine, for forming sets of views and scoring them, by the scoring function; and a set selection routine selecting a set from the collection, based on the scoring function; wherein said set is used for instructing a three dimensional (3D) reconstruction of an intensity distribution in at least some of the volume from radioactive-emission measurements of said selected set of views.
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Specification