Malignancy diagnosis using content-based image retreival of tissue histopathology
First Claim
Patent Images
1. A computer-aided diagnostic method to predict a probability that a histological image contains a malignant region comprising:
- a. obtaining said histological image, wherein the histological image is a first of a series of further histological images ordered in increasing magnification;
b. identifying a region or regions of said histological image classified as suspect;
c. extracting one or more image features from at least one of said identified region or regions;
d. reducing a dimensionality of said extracted feature image features; and
e. classifying said identified region or regions as either benign, malignant, or suspect based on at least one of said extracted image features, wherein if said identified region or regions are classified as malignant, the histological image has a malignant region, otherwise;
i. if the identified region or regions are classified as benign, then the histological image does not have a malignant region;
orii. if the identified region or regions are classified as suspect, a next histological image in the series is obtained and the steps of identifying, extracting, reducing and classifying are repeated.
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Abstract
This invention relates to computer-aided diagnostics using content-based retrieval of histopathological image features. Specifically, the invention relates to the extraction of image features from a histopathological image based on predetermined criteria and their analysis for malignancy determination.
22 Citations
25 Claims
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1. A computer-aided diagnostic method to predict a probability that a histological image contains a malignant region comprising:
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a. obtaining said histological image, wherein the histological image is a first of a series of further histological images ordered in increasing magnification; b. identifying a region or regions of said histological image classified as suspect; c. extracting one or more image features from at least one of said identified region or regions; d. reducing a dimensionality of said extracted feature image features; and e. classifying said identified region or regions as either benign, malignant, or suspect based on at least one of said extracted image features, wherein if said identified region or regions are classified as malignant, the histological image has a malignant region, otherwise; i. if the identified region or regions are classified as benign, then the histological image does not have a malignant region;
orii. if the identified region or regions are classified as suspect, a next histological image in the series is obtained and the steps of identifying, extracting, reducing and classifying are repeated. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 24, 25)
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23. A system for predicting a probability that a histological image contains a malignant region, the system comprising:
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a database for storing a series of further histological images ordered in increasing magnification, the histological image being a first image in the series of further histological images; means for identifying a region or regions of said histological image classified as suspect; a feature extraction module for extracting one or more image features from at least one of said identified region or regions; a manifold learning module for reducing a dimensionality of said extracted image features; and means for classifying said identified region or regions as either benign, malignant, or suspect based on at least one of said extracted image features, wherein if said identified region or regions are classified as malignant, the histological image has a malignant region, otherwise, i. if the identified region or regions are classified as benign, then the histological image does not have a malignant region;
orii. if the identified region or regions are classified as suspect, a next histological image in the series is obtained, the next histological image being processed via the means for identifying, the feature extraction module, the manifold learning module and the means for classifying to classify at least one region of the next histological image as benign, malignant or suspect.
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Specification