Analyte sensor method and apparatus
First Claim
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1. An analyte sensing device comprising:
- a. a sensor body member including at least one nanopore;
b. an optical conduit in optical communication with the sensor body member, the optical conduit transmits optical energy to the sensor body member and receives reflected optical energy back from the sensor body member; and
c. a photodetector optically coupled to the optical conduit to determine an optical parameter from the reflected optical energy,wherein the photodetector is optically coupled to an optical coherence tomography instrument and the optical parameter is correlated with a refractive index of the analyte.
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Abstract
The invention generally relates to systems, methods, and apparatuses for an analyte sensor. In one aspect, an analyte sensing device comprises a sensor body member including at least one nanopore and an optical conduit in optical communication with the sensor body member. The optical conduit transmits optical energy to the sensor body member and receives reflected optical energy back from the sensor body member. A photodetector is optically coupled to the optical conduit to determine an optical parameter from the reflected optical energy.
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Citations
24 Claims
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1. An analyte sensing device comprising:
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a. a sensor body member including at least one nanopore; b. an optical conduit in optical communication with the sensor body member, the optical conduit transmits optical energy to the sensor body member and receives reflected optical energy back from the sensor body member; and c. a photodetector optically coupled to the optical conduit to determine an optical parameter from the reflected optical energy, wherein the photodetector is optically coupled to an optical coherence tomography instrument and the optical parameter is correlated with a refractive index of the analyte. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A method for obtaining optical measurements of an analyte comprising the steps of:
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optically coupling a sensor body element with an optical conduit, the sensor body element includes at least one nanopore and a reflective surface, and the optical conduit is operably associated with a reference reflector; permitting the diffusion of an analyte into the at least one nanopore; transmitting optical energy from the optical conduit to the sensor body element; reflecting optical energy from the sensor body element back to the optical conduit; measuring the reflected optical energy with a detector optically coupled to an optical coherence tomography instrument; and determining a refractive index of the analyte from the measured energy. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23, 24)
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Specification