Vagus nerve stimulation method
First Claim
1. A method of treating a brain disorder in a patient having a cardiac cycle, a vagus nerve, and a brain, the method comprising:
- detecting at least a portion of the cardiac cycle of the patient;
applying to a selected location on the vagus nerve of the patient, in response to having detected the portion of the cardiac cycle of the patient, a pulsed electrical signal configured to increase afferent activity on the vagus nerve to be conducted thereby to the brain to treat the brain disorder, the pulsed electrical signal being selected from the group consisting of a single microburst and a plurality of microbursts, wherein each microburst of the pulsed electrical signal is applied to the selected location on the vagus nerve of the patient, and wherein each microburst of the pulsed electrical signal is patterned and comprises;
from 2 to 6 pulses per microburst;
at least one interpulse interval between adjacent pulses of the microburst, each interpulse interval ranging from about 5 to about 10 milliseconds; and
a microburst duration less than or equal to 100 milliseconds.
1 Assignment
0 Petitions
Accused Products
Abstract
An implanted electrical signal generator delivers a novel exogenous electrical signal to a vagus nerve of a patient. The vagus nerve conducts action potentials originating in the heart and lungs to various structures of the brain, thereby eliciting a vagal evoked potential in those structures. The exogenous electrical signal simulates and/or augments the endogenous afferent activity originating from the heart and/or lungs of the patient, thereby enhancing the vagal evoked potential in the various structures of the brain. The exogenous electrical signal includes a series of electrical pulses organized or patterned into a series of microbursts including 2 to 20 pulses each. No pulses are sent between the microbursts. Each of the microbursts may be synchronized with the QRS wave portion of an ECG. The enhanced vagal evoked potential in the various structures of the brain may be used to treat various medical conditions including epilepsy and depression.
602 Citations
30 Claims
-
1. A method of treating a brain disorder in a patient having a cardiac cycle, a vagus nerve, and a brain, the method comprising:
-
detecting at least a portion of the cardiac cycle of the patient; applying to a selected location on the vagus nerve of the patient, in response to having detected the portion of the cardiac cycle of the patient, a pulsed electrical signal configured to increase afferent activity on the vagus nerve to be conducted thereby to the brain to treat the brain disorder, the pulsed electrical signal being selected from the group consisting of a single microburst and a plurality of microbursts, wherein each microburst of the pulsed electrical signal is applied to the selected location on the vagus nerve of the patient, and wherein each microburst of the pulsed electrical signal is patterned and comprises; from 2 to 6 pulses per microburst; at least one interpulse interval between adjacent pulses of the microburst, each interpulse interval ranging from about 5 to about 10 milliseconds; and a microburst duration less than or equal to 100 milliseconds. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
-
-
17. A method of treating a medical condition in a patient having a cardiac cycle, a respiratory cycle, and a vagus nerve, the method comprising:
-
detecting at least a portion of the cardiac cycle of the patient; detecting at least a portion of the respiratory cycle of the patient, wherein detecting the portion of the respiratory cycle of the patient comprises detecting one of an inspiration of breath and an expiration of breath; and in response to detecting the portion of the cardiac cycle of the patient and the portion of the respiratory cycle of the patient, applying a pulsed electrical signal to the vagus nerve of the patient, the pulsed electrical signal comprising a plurality of microbursts, wherein applying the pulsed electrical signal comprises applying a microburst to the vagus nerve of the patient after a delay period following the detection of one of the inspiration of breath and the expiration of breath, and wherein each microburst is separated from an adjacent microburst by an interburst period of at least 100 milliseconds and each microburst is characterized by; from 2 to 20 pulses per microburst; an interpulse interval between adjacent pulses of the microburst of from about 1 to about 20 milliseconds; and a microburst duration of not greater than 1 second. - View Dependent Claims (18, 19)
-
-
20. A method of treating a medical condition in a patient having a cardiac cycle, a vagus nerve, and a brain, the method comprising:
-
applying a first pulsed electrical signal comprising a plurality of microbursts to the vagus nerve of the patient; measuring a first enhanced Vagal Evoked Potential (eVEP) in a target area of the patient'"'"'s brain; changing at least one of a number of pulses per microburst, an interpulse interval between adjacent pulses of the microburst, a microburst duration, and an interburst period to provide a second pulsed electrical signal comprising a plurality of microbursts; applying the second pulsed electrical signal to the vagus nerve of the patient; measuring a second eVEP in the target area of the patient'"'"'s brain; comparing the first eVEP and the second eVEP; selecting one of the first electrical signal and the second electrical signal for continued application to the vagus nerve of the patient based upon the comparing; detecting at least a portion of the cardiac cycle of the patient; and in response to detecting the portion of the cardiac cycle of the patient, applying the selected electrical signal to the vagus nerve of the patient, wherein each of the microbursts of the first and second electrical signals is separated from an adjacent microburst by an interburst period of at least 100 milliseconds and each microburst is characterized by; from 2 to 20 pulses per microburst; an interpulse interval between adjacent pulses of the microburst of from about 1 to about 20 milliseconds; and a microburst duration of not greater than 1 second. - View Dependent Claims (21)
-
-
22. A method comprising:
-
for a patient having a brain, a vagus nerve, a cardiac cycle, and a neuropsychiatric disorder, detecting an R-wave of the cardiac cycle of the patient; applying to a selected location on the vagus nerve of the patient, in response to having detected the R-wave of the cardiac cycle of the patient, a pulsed electrical signal configured to increase afferent activity on the vagus nerve to be conducted thereby to the brain to treat the neuropsychiatric disorder, the pulsed electrical signal being selected from the group consisting of a single microburst and a plurality of microbursts, wherein each microburst of the pulsed electrical signal is applied to the selected location on the vagus nerve of the patient, and wherein each microburst of the pulsed electrical signal is patterned and comprises; from 2 to 6 pulses per microburst; at least one interpulse interval between adjacent pulses of the microburst, each interpulse interval ranging from about 5 to about 10 milliseconds; and a microburst duration less than or equal to 100 milliseconds. - View Dependent Claims (23)
-
-
24. A method of treating a brain disorder in a patient having a cardiac cycle, a vagus nerve, and a brain, the method comprising:
-
detecting at least a portion of the cardiac cycle of the patient; applying to a selected location on the vagus nerve of the patient, in response to having detected the portion of the cardiac cycle of the patient, a pulsed electrical signal configured to increase afferent activity on the vagus nerve to be conducted thereby to the brain to treat the brain disorder, the pulsed electrical signal being selected from the group consisting of a single microburst and a plurality of microbursts, wherein each microburst of the pulsed electrical signal is applied to the selected location on the vagus nerve of the patient, and wherein each microburst of the pulsed electrical signal is patterned and comprises; a plurality of pulses per microburst; a plurality of interpulse intervals between adjacent pulses of the microburst, wherein each interpulse interval is between about 5 to about 10 milliseconds, and wherein at least one interpulse interval of the plurality of interpulse intervals in each microburst is selectively varied from the other interpulse intervals; and a microburst duration less than or equal to 100 milliseconds. - View Dependent Claims (25, 26, 27, 28, 29, 30)
-
Specification