Method for exclusion of ectopic events from heart rate variability metrics

• US 8,280,510 B2
• Filed: 06/23/2011
• Issued: 10/02/2012
• Est. Priority Date: 11/02/2000
• Status: Expired due to Fees

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Dyjach, John A., Carlson, Gerrard M.
• Primary Examiner(s): MANUEL, GEORGE C
• Application Number:
  US13/167,621
• Publication Number:
  US 20110257698A1
• Time in Patent Office: 467 Days
• Field of Search: 607/9
• US Class Current: 607/9
• CPC Class Codes: A61B 5/364 Detecting abnormal ECG interval, e.g. extrasystoles, ectopic heartbeats
• CPC Class Codes: A61B 5/4035 Evaluating the autonomic nervous system
• CPC Class Codes: A61N 1/3622 comprising two or more electrodes co-operating with different heart regions

Abstract

Heart rate variability metrics are derived from the intervals between successive heart beats, referred to as BB intervals. A method implementable by an implantable cardiac device for excluding BB intervals due to ectopic beats based on a function of preceding BB intervals is presented. It is desirable to remove such BB intervals from a BB interval time series used to calculate a heart rate variability metric.

Claims

1. A method for operating a cardiac device, comprising:

sensing electrical activity in a cardiac chamber and generating a chamber sense signal when the sensed electrical activity exceeds a predetermined threshold;

measuring time intervals between each pair of successive chamber senses, referred to as BB intervals, the measured BB intervals constituting a BB time series;

filtering the BB intervals to exclude particular BB intervals as ectopic using a buffer for storing a plurality of BB intervals by;

1) acquiring a present BB interval,

2) if the buffer contains less than N intervals, classifying the present BB interval as indeterminate, storing the indeterminately classified BB interval in the buffer, and returning to step 1,

3) if the buffer contains N intervals, computing a statistic from the stored BB intervals and comparing the present BB interval to the computed statistic,

4) excluding the present BB interval as an ectopic interval if the present BB interval is greater or less than the computed statistic by a specified threshold value, removing the oldest BB interval from the buffer, and returning to step 1,

5) updating the buffer by removing the oldest BB interval and storing the present BB interval therein if the present BB interval is not excluded as ectopic and then returning to step 1; and

computing a heart rate variability metric from the filtered BB intervals.

2. The method of claim 1 wherein the computed statistic is a median value of the plurality of preceding BB intervals.

3. The method of claim 1 wherein the computed statistic is a weighted average of the plurality of preceding BB intervals.

4. The method of claim 1 wherein the chamber senses are ventricular senses and the BB intervals are RR intervals.

5. The method of claim 1 wherein the specified threshold value is a specified percentage of the computed statistic.

6. The method of claim 1 further comprising filtering the BB intervals by:

if the present BB interval is above or below specified upper and lower limit values, excluding the present BB interval as ectopic and removing the oldest BB interval from the buffer.

7. The method of claim 1 wherein the heart rate variability metric is a parameter computed by time-domain filtering of the filtered BB intervals.

8. The method of claim 1 wherein the heart rate variability metric is a parameter computed by frequency domain analysis of the filtered BB intervals.

9. The method of claim 1 wherein the heart rate variability metric is a statistical surrogate of a frequency component of the filtered BB intervals.

10. The method of claim 1 wherein the heart rate variability metric is a ratio of high-frequency and low-frequency components of the filtered BB intervals.

11. A cardiac rhythm management device, comprising:

a sensing amplifier for sensing electrical activity in a cardiac chamber;

a controller interfaced to the sensing amplifier which detects a chamber sense when the sensed electrical activity exceeds a predetermined threshold;

wherein the controller is programmed with executable instructions for;

measuring time intervals between each pair of successive chamber senses, referred to as BB intervals, the measured BB intervals constituting a BB time series;

filtering the BB intervals to exclude particular BB intervals as ectopic using a buffer for storing a plurality of previous BB intervals and from which a statistic is computed, where the buffer can contain a maximum number N of such preceding BB intervals, by;

1) acquiring a present BB interval,

2) if the buffer contains less than N intervals, classifying the present BB interval as indeterminate, storing the indeterminately classified BB interval in the buffer, and returning to step 1,

3) if the buffer contains N intervals, computing a statistic from the stored BB intervals and comparing the present BB interval to the computed statistic,

4) excluding the present BB interval as an ectopic interval if the present BB interval is greater or less than the computed statistic by a specified threshold value, removing the oldest BB interval from the buffer, and returning to step 1,

5) updating the buffer by removing the oldest BB interval and storing the present BB interval therein if the present BB interval is not excluded as ectopic and then returning to step 1; and

,

computing a heart rate variability metric from the filtered BB intervals.

12. The device of claim 11 wherein the computed statistic is a median value of the plurality of preceding BB intervals.

13. The device of claim 11 wherein the computed statistic is a weighted average of the plurality of preceding BB intervals.

14. The device of claim 11 wherein the chamber senses are ventricular senses and the BB intervals are RR intervals.

15. The device of claim 11 wherein the specified threshold value is a specified percentage of the computed statistic.

16. The device of claim 11 wherein the controller is further programmed to filter the BB intervals by:

if the present BB interval is above or below specified upper and lower limit values, excluding the present BB interval as ectopic and removing the oldest BB interval from the buffer.

17. The device of claim 11 wherein the heart rate variability metric is a parameter computed by time-domain filtering of the filtered BB intervals.

18. The device of claim 11 wherein the heart rate variability metric is a parameter computed by frequency domain analysis of the filtered BB intervals.

19. The device of claim 11 wherein the heart rate variability metric is a statistical surrogate of a frequency component of the filtered BB intervals.

20. The device of claim 11 wherein the heart rate variability metric is a ratio of high-frequency and low-frequency components of the filtered BB intervals.