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Sterile hyaluronic acid solutions

  • US 8,283,463 B2
  • Filed: 02/09/2010
  • Issued: 10/09/2012
  • Est. Priority Date: 02/09/2010
  • Status: Active Grant
First Claim
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1. A process for sterilizing a solution, the process comprising:

  • providing an aqueous solution of hyaluronic acid having a weight average molecular weight from 0.6 MDa to 3.6 MDa, and the concentration of the hyaluronic acid is from 0.04% to 0.8% by weight;

    wherein the aqueous solution has an ionic strength equivalent to an aqueous concentration of sodium chloride from 3% to 30% by weight to provide a high salt, hyaluronic acid solution;

    maintaining the aqueous high salt, hyaluronic acid solution at a temperature from 40°

    C. to 80°

    C. for at least 1 hour and not longer than six days; and

    filtering the heated, high salt, hyaluronic acid solution through a sterilization filter medium, wherein the filter medium has an average pore size of 0.25 μ

    m or less to provide a sterilized high salt, hyaluronic acid solution.

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