Transgenic mouse models of Aβ overexpression
First Claim
Patent Images
1. A transgenic non-human animal whose genome comprises:
- a DNA transgene encoding at least one Aβ
peptide consisting of Aβ
N3E-42 (SEQ ID NO;
1), Aβ
N3Q-42 (SEQ ID NO;
2), Aβ
N3E-40 (SEQ ID NO;
3) or Aβ
N3Q-40 (SEQ ID NO;
4).
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Abstract
A transgenic non-human animal, in particular a transgenic mouse encoding Aβ peptide proteins, which have been implicated in Aβ peptide-related diseases. Cells and cell lines comprising transgenes encoding for Aβ peptide. Methods and compositions for evaluating agents that affect Aβ peptide, for use in compositions for the treatment of Aβ peptide-related diseases.
40 Citations
29 Claims
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1. A transgenic non-human animal whose genome comprises:
- a DNA transgene encoding at least one Aβ
peptide consisting of Aβ
N3E-42 (SEQ ID NO;
1), Aβ
N3Q-42 (SEQ ID NO;
2), Aβ
N3E-40 (SEQ ID NO;
3) or Aβ
N3Q-40 (SEQ ID NO;
4). - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
- a DNA transgene encoding at least one Aβ
-
21. A transgenic mouse comprising:
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a transgenic nucleotide sequence encoding Aβ
peptide operably linked to a promoter integrated into the genome of the mouse,wherein, the transgene encodes a peptide consisting of Aβ
N3E-42 (SEQ ID NO;
1), Aβ
N3Q-42 (SEQ ID NO;
2), Aβ
N3E-40 (SEQ ID NO;
3) or Aβ
N3Q-40 (SEQ ID NO;
4); andthe mouse demonstrates a phenotype that can be reversed or ameliorated with an Aβ
peptide inhibitor of Aβ
peptide effects.- View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 29)
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Specification