Method and apparatus for enhancement of transdermal transport
First Claim
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1. A method for enhancing a permeability of an area of skin for drug delivery or analyte extraction comprising:
- increasing the permeability of the area of skin with a skin permeabilizing device, wherein the skin permeabilizing device comprises a permeability monitoring circuit for monitoring at least one electrical parameter of the area of skin indicative of skin permeability and wherein the skin permeabilizing device permeabilizes the skin using mechanical force;
applying electricity in the form of an alternating current to the area of skin;
monitoring the at least one electrical parameter of the area of skin using the permeability monitoring circuit of the skin permeabilizing device; and
controlling the mechanical force applied to the area of skin by the skin permeabilizing device based on the at least one electrical parameter,wherein after the permeability of the skin is increased, the analyte or drug is able to passively diffuse through the skin.
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Abstract
According to the present invention, a method for enhancing transdermal transport is disclosed. The method includes the steps of increasing a permeability of an area of a membrane with a permeabilizing device. The membrane may be, inter alia, biologic skin or synthetic skin. The permeabilizing device may be an ultrasound-producing device. A substance is transported into and through the area of the membrane. The substance may be a drug, a vaccine, or a component of interstitial fluid.
169 Citations
22 Claims
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1. A method for enhancing a permeability of an area of skin for drug delivery or analyte extraction comprising:
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increasing the permeability of the area of skin with a skin permeabilizing device, wherein the skin permeabilizing device comprises a permeability monitoring circuit for monitoring at least one electrical parameter of the area of skin indicative of skin permeability and wherein the skin permeabilizing device permeabilizes the skin using mechanical force; applying electricity in the form of an alternating current to the area of skin; monitoring the at least one electrical parameter of the area of skin using the permeability monitoring circuit of the skin permeabilizing device; and controlling the mechanical force applied to the area of skin by the skin permeabilizing device based on the at least one electrical parameter, wherein after the permeability of the skin is increased, the analyte or drug is able to passively diffuse through the skin. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. An apparatus for enhancing permeability of an area of skin comprising:
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a skin permeabilizing device configured to increase a permeability of the area of skin using mechanical force; an electrical source operable to apply electricity in the form of an alternating current to the area of skin; a permeability monitoring circuit to monitor at least one electrical parameter of the area of skin indicative of skin permeability; and a controller responsive to the permeability monitoring circuit and operable to control the mechanical force applied to the area of the skin by the skin permeabilizing device based on the at least one electrical parameter of the area of skin. - View Dependent Claims (19, 20, 21, 22)
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Specification