Liquid sample measurement method and apparatus

• US 8,287,718 B2
• Filed: 07/04/2007
• Issued: 10/16/2012
• Est. Priority Date: 07/05/2006
• Status: Active Grant

• Current Assignee: PHC Holdings Corporation
• Original Assignee: Panasonic Corporation (Panasonic Holdings Corporation)
• Inventors: Shinno, Teppei, Takahara, Yoshifumi
• Primary Examiner(s): Olsen, Kaj K
• Assistant Examiner(s): Carlson, Kourtney R
• Application Number:
  US12/307,340
• Publication Number:
  US 20090236237A1
• Time in Patent Office: 1,931 Days
• Field of Search: 20440301-40315, 205/777.5, 205/778, 205/792, 600345-348
• US Class Current: 205/792
• CPC Class Codes: C12Q 1/54 involving glucose or galactose
• CPC Class Codes: G01N 27/3274 Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration coding of calibration information G01N33/48771
• CPC Class Codes: G01N 33/5438 Electrodes
• CPC Class Codes: G01N 33/54393 Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding

Abstract

A liquid sample measurement apparatus of the present invention is provided with a timer for measuring the time from when a biosensor is attached to a liquid sample measurement device which measures the concentration of a specific component in a liquid sample that is applied to the biosensor to when the liquid sample is applied to the biosensor, and correction based on the time measured by the timer is performed to the measurement result of the concentration of the specific component in the liquid sample that is applied to the biosensor. Thereby, the measurement precision can be enhanced with utilizing the correction algorithm in which the ambient temperature and the temperature of the biosensor itself are considered.

Claims

1. A liquid sample measurement method, comprising:

attaching a biosensor to a measurement device;

applying a liquid sample to the biosensor;

measuring a concentration of a specific component in the liquid sample that is applied to the biosensor;

measuring the time from when the biosensor is attached to the measurement device to when the liquid sample is applied to the biosensor; and

performing a correction for the measurement result of the concentration of the specific component in the liquid sample that is applied to the biosensor, on the basis of the measured time.

2. A liquid sample measurement method as defined in claim 1,

wherein the amount of the correction for the measurement result of the concentration of the specific component in the liquid sample that is applied to the biosensor is varied according to the measured time from when the biosensor is attached to the measurement device to when the liquid sample is applied to the biosensor.

3. A liquid sample measurement method as defined in claim 2,

wherein the amount of the correction is reduced when the measured time from when the biosensor is attached to the measurement device to when the liquid sample is applied to the biosensor is long.

4. A liquid sample measurement method as defined in claim 1,

wherein whether or not the correction should be performed for the measurement result of the concentration of the specific component in the liquid sample that is applied to the biosensor is judged according to the measured time from when the biosensor is attached to the measurement device to when the liquid sample is applied to the biosensor.

5. A liquid sample measurement method as defined in claim 4,

wherein the correction is performed when the measured time from when the biosensor is attached to the measurement device to when the liquid sample is applied to the biosensor is within a specific time period.

6. A liquid sample measurement method as defined in claim 1,

wherein the amount of the correction for the measurement result is determined according to the measurement result of the concentration of the specific component in the liquid sample that is applied to the biosensor.

7. A liquid sample measurement method as defined in claim 1,

wherein the amount of the correction for the measurement result of the concentration of the specific component in the liquid sample that is applied to the biosensor is determined according to the ambient temperature at the measurement.

8. A liquid sample measurement method as defined in claim 1,

wherein the amount of the correction for the measurement result of the concentration of the specific component in the liquid sample that is applied to the biosensor is determined according to a second specific component which exists in the liquid sample and is different than the specific component.

9. A liquid sample measurement method as defined in claim 8,

wherein the liquid sample is blood, and

wherein the amount of the correction is determined according to the hematocrit value of the blood.

10. A liquid sample measurement method as defined in claim 1,

wherein the amount of the correction for the measurement result is determined according to the kind of the liquid sample that is applied to the biosensor.

11. A liquid sample measurement method, comprising:

attaching a biosensor to a measurement device;

applying a liquid sample to the biosensor;

measuring concentrations of a plurality of specific components in the liquid sample that is applied to the biosensor;

measuring the time from when the biosensor is attached to the measurement device to when the liquid sample is applied to the biosensor; and

performing, for each of the plurality of specific components in the liquid sample that is applied to the biosensor, a correction for the measurement result of the concentration of the specific component in the liquid sample that is applied to the biosensor, on the basis of the measured time.

12. A liquid sample measurement method as defined in claim 11,

wherein the amount of the correction for the measurement result of the concentration of the specific component in the liquid sample that is applied to the biosensor is varied according to the measured time from when the biosensor is attached to the measurement device to when the liquid sample is applied to the biosensor.

13. A liquid sample measurement method as defined in claim 11,

wherein whether or not the correction should be performed for the measurement result of the concentration of the specific component in the liquid sample that is applied to the biosensor is judged according to the measured time from when the biosensor is attached to the measurement device to when the liquid sample is applied to the biosensor.

14. A liquid sample measurement method as defined in claim 11,

wherein the amount of the correction for the measurement result is determined according to the measurement result of the concentration of the specific component in the liquid sample that is applied to the biosensor.

15. A liquid sample measurement method as defined in claim 11,

wherein the amount of the correction for the measurement result of the concentration of the specific component in the liquid sample that is applied to the biosensor is determined according to the ambient temperature at the measurement.

16. A liquid sample measurement method as defined in claim 11,

wherein the amount of the correction for the measurement result of the concentration of the specific component in the liquid sample that is applied to the biosensor is determined according to a second specific component which exists in the liquid sample and is different than the specific component.

17. A liquid sample measurement method as defined in claim 11,

wherein the amount of the correction for the measurement result is determined according to the kind of the liquid sample that is applied to the biosensor.

18. A liquid sample measurement method, comprising:

attaching a plurality of biosensors to a measurement device;

applying a plurality of liquid samples to the plurality of biosensors, respectively;

measuring concentrations of specific components in the plurality of liquid samples that are applied to the plurality of biosensors;

measuring, for each of the plurality of biosensors, the time from when the biosensor is attached to the measurement device to when the corresponding liquid sample is applied to the biosensor; and

performing, for each of the plurality of biosensors, a correction for the measurement result of the concentration of the specific component in the corresponding liquid sample that is applied to the biosensor, on the basis of the measured time and the type of the biosensor.

19. A liquid sample measurement method as defined in claim 18,

wherein the amount of the correction for the measurement result of the concentration of the specific component in the corresponding liquid sample that is applied to the biosensor is varied according to the measured time from when the biosensor is attached to the measurement device to when the corresponding liquid sample is applied to the biosensor.

20. A liquid sample measurement method as defined in claim 18,

wherein whether or not the correction should be performed for the measurement result of the concentration of the specific component in the corresponding liquid sample that is applied to the biosensor is judged according to the measured time from when the biosensor is attached to the measurement device to when the corresponding liquid sample is applied to the sensor.

21. A liquid sample measurement method as defined in claim 18,

wherein the amount of the correction for the measurement result is determined according to the measurement result of the concentration of the specific component in the corresponding liquid sample that is applied to the biosensor.

22. A liquid sample measurement method as defined in claim 18,

wherein the amount of the correction for the measurement result of the concentration of the specific component in the corresponding liquid sample that is applied to the biosensor is determined according to the ambient temperature at the measurement.

23. A liquid sample measurement method as defined in claim 18,

wherein the amount of the correction for the measurement result of the concentration of the specific component in the corresponding liquid sample that is applied to the biosensor is determined according to a second specific component which exists in the corresponding liquid sample and is different than the specific component.

24. A liquid sample measurement method as defined in claim 18,

wherein the amount of the correction for the measurement result is determined according to the kind of the corresponding liquid sample that is applied to the biosensor.