Device for synthesis of radiopharmaceutical products

• US 8,287,819 B2
• Filed: 12/12/2001
• Issued: 10/16/2012
• Est. Priority Date: 12/22/2000
• Status: Active Grant

• Current Assignee: Ion Beam Applications s.a.
• Original Assignee: Ion Beam Applications s.a.
• Inventors: Boeyen, Pierre-Emmanuel, Tadino, Vincent, Schmitz, Fèdèric
• Primary Examiner(s): Turk, Neil N
• Application Number:
  US10/450,308
• Publication Number:
  US 20040028573A1
• Time in Patent Office: 3,961 Days
• Field of Search: 422/104, 422/61, 422/102, 206/161, 206/167, 248/326, 248/335
• US Class Current: 422/501
• CPC Class Codes: A61K 51/04 Organic compounds
• CPC Class Codes: A61K 51/0491 Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
• CPC Class Codes: A61K 51/1282 Devices used in vivo and carrying the radioactive therapeutic or diagnostic agent, therapeutic or in vivo diagnostic kits, stents

Abstract

The invention concerns a device for synthesis of radiopharmaceutical products based on chemical reagents contained in bottles, said device comprising several reaction compartments, transfer means between said bottles and said reaction compartments as well as mechanical means acting on said transfer means and enabling to monitor and control mechanically the transfer of chemical reagents. The invention is characterized in that it comprises: a fixed module including at least the mechanical means; a removable and disposable module, essentially in the shape of a support, whereon are arranged the transfer means between said bottles and said reaction compartments, said removable and disposable module not including any mechanical means; and means for securing said removable and disposable module to said fixed module.

Claims

1. A device which synthesizes radiopharmaceutical products from chemical reagents, the device comprising:

a fixed module which includes pinch valves;

a disposable module; and

a mounting device which removably secures the disposable module to the fixed module, the disposable module comprising;

a support plate having grooves, the grooves having widened areas;

bottles configured to contain and provide pre-metered amounts of the chemical reagents;

one or more reaction compartments located in the disposable module; and

flexible tubes configured to deliver the chemical reagents from the bottles to the one or more reaction compartments, wherein the tubes in the disposable module are positioned in the grooves on the support plate in the disposable module and the support plate is configured to position the tubes adjacent the pinch valves in the fixed module and which pinch valves pinch the tubes to control the flow of the chemical reagents from the bottles in the disposable module to the one or more reaction compartments in the disposable module to provide the radiopharmaceutical products, the disposable module not including a mechanical device which controls the flow of chemical reagents through the tubes; and

wherein the pinch valves in the fixed module comprise one or more pistons acting on the flexible tubes of the disposable module, the pistons configured to engage the flexible tubes and effect control of the transfer of the chemical reagents from the bottles of the disposable module, and wherein the pistons are located opposite the widened areas of the grooves to permit the flexible tubes to compress and the pistons and the tubes to co-operate to form valves.