Three-dimensional biological scaffold compromising polymer waveguides

• US 8,287,895 B1
• Filed: 04/24/2008
• Issued: 10/16/2012
• Est. Priority Date: 04/24/2008
• Status: Active Grant

• Current Assignee: HRL Laboratories LLC (The Boeing Co.)
• Original Assignee: HRL Laboratories LLC (The Boeing Co.)
• Inventors: Jacobsen, Alan J., Zhou, Chaoyin, Kisailus, David
• Primary Examiner(s): Naff, David
• Application Number:
  US12/109,262
• Time in Patent Office: 1,636 Days
• Field of Search: None
• US Class Current: 424/423
• CPC Class Codes: A61L 27/30 Inorganic materials
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: C12M 25/14 Scaffolds; Matrices in general C12N5/0068

Abstract

A three-dimensional biological scaffold. The scaffold includes at least three sets of polymer waveguides extending along at least three respective directions. The at least three sets of polymer waveguides interpenetrate each other at a plurality of nodes to form a self-supporting structure. In some embodiments, the polymer waveguides may be bio-degradable. In still some embodiments, the three-dimensional biological scaffold may include one or more coating layers for covering surfaces of the polymer waveguides.

Claims

1. A three-dimensional biological scaffold comprising:

at least three sets of bio-degradable polymer waveguides extending along at least three different directions,

wherein the at least three sets of bio-degradable polymer waveguides interpenetrate each other at a plurality of nodes to form a self-supporting structure having a plurality of ordered interconnected pores, at least three of the bio-degradable polymer waveguides intersecting each other at a node of the plurality of nodes at non-perpendicular angles, and

wherein the plurality of ordered interconnected pores are sized to facilitate ingress of at least one of biological cells, vascular tissue, or nutrient media.

2. The three-dimensional biological scaffold of claim 1, wherein the plurality of ordered interconnected pores are sized to about 100 μ

m to 300 μ

m.

3. The three-dimensional biological scaffold of claim 1, wherein a bio-degradable polymer waveguide of the at least three sets of bio-degradable polymer waveguides has a cross-sectional diameter about 1 μ

m to about 1 mm.

4. The three-dimensional biological scaffold of claim 1, wherein the plurality of ordered interconnected pores occupy a free space of not less than about 40% by volume and not greater than about 99% by volume of the self-supporting structure.

5. The three-dimensional biological scaffold of claim 1, wherein the at least three sets of bio-degradable polymer waveguides comprise a bio-degradable polymer selected from one of starches, starch-similar polymers, starch-synthetic blend polymers, esters, amides, anhydrides, urethanes, ureas, carbonates, or saccharides.

6. The three-dimensional biological scaffold of claim 1, wherein surfaces of the three-dimensional biological scaffold are treated with a material selected from the group consisting of a silane, a biphasic calcium phosphate, a bone morphogenetic protein, and a polysaccharide.

7. A three-dimensional biological scaffold comprising:

at least three sets of polymer waveguides extending along at least three different directions; and

one or more coating layers on surfaces of the at least three sets of polymer waveguides,

wherein the at least three sets of polymer waveguides interpenetrate each other at a plurality of nodes to form a self-supporting structure having a plurality of ordered interconnected pores, at least three of the polymer waveguides intersecting each other at a node of the plurality of nodes at non-perpendicular angles, and

wherein the plurality of ordered interconnected pores are sized to facilitate ingress of at least one of biological cells, vascular tissue, or nutrient media.

8. The three-dimensional biological scaffold of claim 7, wherein the plurality of ordered interconnected pores are sized to about 100 μ

m to 300 μ

m.

9. The three-dimensional biological scaffold of claim 7, wherein the one or more coating layers comprise one of metal or ceramic.

10. The three-dimensional biological scaffold of claim 9, wherein the one or more coating layers comprise a material selected from one of titanium (Ti), nickel (Ni), Ti6Al4V, or nickel alloy.

11. The three-dimensional biological scaffold of claim 9, wherein the one or more coating layers comprise a material selected from one of silicon carbide (SiC), silicon nitride (Si3N4), hafnium carbide (HfC), chromium carbide (Cr3C2), boron nitride (B4N), cubic boron nitride (c-BN), hexagonal boron nitride (h-BN), boron carbide (B4C), aluminum oxide (Al2O3), titanium diboride (TiB2), titanium nitride (TiN), or zirconium dioxide (ZrO2).

12. The three-dimensional biological scaffold of claim 7, wherein a polymer waveguide of the at least three sets of polymer waveguides has a cross-sectional diameter from about 1 μ

m to about 1 mm.

13. The three-dimensional biological scaffold of claim 12, wherein the polymer waveguide has a cross-sectional diameter from about 100 μ

m to about 500 μ

m.

14. The three-dimensional biological scaffold of claim 7, wherein the plurality of ordered interconnected pores occupy a free space of not less than about 40% by volume and not greater than about 99% by volume of the self-supporting structure.

15. The three-dimensional biological scaffold of claim 14, wherein the free space is not less than about 70% by volume and not greater than about 90% by volume of the self-supporting structure.

16. The three-dimensional biological scaffold of claim 7, wherein surfaces of the three-dimensional biological scaffold are treated with a material selected from the group consisting of a silane, a bi-phasic calcium phosphate, a bone morphogenetic protein, and a polysaccharide.