Compositions and methods for treating immune disorders

• US 8,287,923 B2
• Filed: 06/09/2006
• Issued: 10/16/2012
• Est. Priority Date: 06/10/2005
• Status: Expired due to Fees

• Current Assignee: Medical College of Georgia (University System of Georgia)
• Original Assignee: Medical College of Georgia (University System of Georgia)
• Inventors: Hsu, Stephen D., Lapp, Carol A., Schuster, George S.
• Primary Examiner(s): Flood, Michele C.
• Application Number:
  US11/916,832
• Publication Number:
  US 20090062379A1
• Time in Patent Office: 2,321 Days
• Field of Search: None
• US Class Current: 424/729
• CPC Class Codes: A61K 31/353 3,4-Dihydrobenzopyrans, e.g. chroman, catechin
• CPC Class Codes: A61K 31/7048 having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin , digitoxin or digoxin
• CPC Class Codes: A61K 36/82 Theaceae (Tea family), e.g. camellia
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 19/02 for joint disorders, e.g. arthritis, arthrosis
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: A61P 37/02 Immunomodulators
• CPC Class Codes: A61P 7/06 Antianaemics

Abstract

Green tea polyphenol compositions and methods of their use are provided. Certain aspects provide methods for modulating expression of one or more autoantigens using the disclosed green tea polyphenol compositions. Representative green tea polyphenols include, but are not limited to (−)-epigallocatechin-3-gallate. Other aspects provide methods for treating autoimmune disease.

Claims

1. A method for treating one or more symptoms of Sjö

gren'"'"'s syndrome in a human subject comprising

administering to a subject in need thereof one or more green tea polyphenols in an amount effective to decrease expression of one or more autoantigens in one or more salivary gland cells of the subject, wherein the one or more symptoms of Sjö

gren'"'"'s syndrome are selected from the group consisting of xerostomia and xerophthalmia.

2. The method of claim 1, wherein the one or more green tea polyphenols comprise (−

)-epigallocatechin-3-gallate or a pharmaceutically acceptable salt thereof.

3. The method of claim 1, wherein the autoantigen is selected from the group consisting of SS-A, SS-B, fodrin, centromere protein, golgin-67, coilin, and Poly (ADP-ribose) polymerase (PARP).

4. The method of claim 1, wherein the one or more green tea polyphenols comprise (−

)-epicatechin, (−

)-epigallocatechin, (−

)-epicatechin-3-gallate, proanthocyanidins combinations thereof.

5. The method of claim 1, wherein expression of at least two autoantigens is decreased relative to a control.