Endoprosthese

• US 8,287,937 B2
• Filed: 04/24/2009
• Issued: 10/16/2012
• Est. Priority Date: 04/24/2009
• Status: Expired due to Fees

• Current Assignee: Boston Scientific Scimed, Inc. (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed, Inc. (Boston Scientific Corporation)
• Inventors: Radhakrishnan, Rajesh, Schewe, Scott R., Schoenle, Victor
• Primary Examiner(s): Meeks, Timothy
• Assistant Examiner(s): SELLMAN, CACHET I
• Application Number:
  US12/429,411
• Publication Number:
  US 20100272882A1
• Time in Patent Office: 1,271 Days
• Field of Search: 427/2.1, 427/2.24, 427/2.25, 427/457, 427/230, 427/299, 427/300, 427/307, 623/1.15, 623/1.42, 623/1.44, 623/1.46, 118/500
• US Class Current: 427/2.1
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61L 33/00 Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
• CPC Class Codes: C23C 14/046 Coating cavities or hollow spaces, e.g. interior of tubes; Infiltration of porous substrates
• CPC Class Codes: C23C 14/22 characterised by the process of coating

Abstract

A coating having a smooth orange peel morphology is formed on an adluminal surface of a stent, concurrently with the formation of a coating having a rough rice grain morphology on an abluminal surface of the stent. During the formation of the two coatings, a mandrel is placed adjacent to the adluminal surface of the stent but does not generally contact the adluminal surface.

Claims

1. A method of making an endoprosthesis using a preform having an abluminal surface and an adluminal surface, the method comprising:

concurrently forming a first coating having an orange peel morphology on the adluminal surface and a second coating having a rice grain morphology on the abluminal surface by;

placing a mandrel surface adjacent to the adluminal surface before forming the first coating and the second coating, and

causing the mandrel surface to roll into occasional contact with the second coating on the adluminal surface when forming the first and second coatings.

2. The method of claim 1, comprising placing the mandrel surface an average distance of at least 20 nm from the adluminal surface.

3. The method of claim 1, comprising placing the mandrel surface an average distance of about 5 mm or less from the adluminal surface.

4. The method of claim 1, wherein the mandrel includes a pattern selected from the group consisting of grooves, knurls, pyramid, columnar, dimpled, and micro-roughened.

5. The method of claim 1, wherein the preform comprises a material having a first thermal mass and the mandrel includes a material having a thermal mass different from the first thermal mass.

6. The method of claim 1, wherein the mandrel comprises a material selected from the group consisting of conducting materials, insulating materials, magnetic materials and non-magnetic materials.

7. The method of claim 1, further comprising providing a temperature gradient between the preform and the mandrel.

8. The method of claim 1, wherein concurrently forming the first coating and the second coating comprises applying a magnetic field.

9. The method of claim 1, wherein concurrently forming the first coating and the second coating comprises applying an electrical field.

10. The method of claim 1, wherein the first coating and the second coating are formed using physical vapor deposition.

11. The method of claim 1, wherein the first coating and the second coating are formed using glancing angle deposition.

12. The method of claim 1, wherein the first coating and the second coating are formed using sputtering.

13. The method of claim 1, wherein the first and second coatings comprise a metal selected from the group consisting of tantalum, chromium, titanium, and iridium.

14. The method of claim 1, wherein the first and second coatings comprise a ceramic selected from the group consisting of titanium nitride, titanium oxide, titanium oxi-nitride, and iridium oxide.

15. The method of claim 1, wherein the first coating has a thickness of about 10 nm to about 50 nm.

16. The method of claim 1, wherein the second coating has a thickness of about 200 nm to about 300 nm.

17. The method of claim 1, wherein the first coating has a thickness of about 10 nm to about 50 nm and the second coating has a thickness of about 200 nm to about 300 nm.

18. A method of making an endoprosthesis using a preform having an abluminal surface and an adluminal surface, the method comprising:

concurrently forming a first coating having an orange peel morphology on the adluminal surface and a second coating having a rice grain morphology on the abluminal surface by placing a mandrel adjacent to the adluminal surface before forming the first coating and the second coating, wherein the mandrel includes a pattern selected from the group consisting of grooves, knurls, pyramid, columnar, dimpled, and micro-roughened.

19. The method of claim 18, wherein the first coating and the second coating are formed using physical vapor deposition.

20. The method of claim 18, wherein the first coating and the second coating are formed using glancing angle deposition.

21. The method of claim 18, wherein the first coating and the second coating are formed using sputtering.