Waveguide-based optical scanning systems
First Claim
Patent Images
1. A scanning sensor system for detecting a biologically active analyte comprising:
- a light source;
a detector;
a substrate comprising a plurality of waveguides and a plurality of optical sensing sites in optical communication with one or more of the waveguides, wherein the optical sensing sites comprise wells, further wherein the waveguides are multi-mode; and
at least one adapter configured to couple with the substrate and provide optical communication between the light source, the waveguides of the substrate, and the detector.
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Abstract
A scanning sensor system, methods of use and kits for detecting a biologically active analyte are provided. The scanning sensor system includes a light source, a detector, a substrate comprising a plurality of waveguides and a plurality of optical sensing sites in optical communication with one or more waveguide of the substrate, and at least one adapter configured to couple with the substrate and provide optical communication between the light source, the waveguides of the substrate, and the detector.
248 Citations
61 Claims
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1. A scanning sensor system for detecting a biologically active analyte comprising:
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a light source; a detector; a substrate comprising a plurality of waveguides and a plurality of optical sensing sites in optical communication with one or more of the waveguides, wherein the optical sensing sites comprise wells, further wherein the waveguides are multi-mode; and at least one adapter configured to couple with the substrate and provide optical communication between the light source, the waveguides of the substrate, and the detector. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 61)
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55. A kit for assaying a sample for a biologically active analyte comprising:
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a scanning sensor system comprising a light source, a detector, a substrate comprising a plurality of waveguides and a plurality of optical sensing sites in optical communication with one or more waveguide of the substrate, wherein the optical sensing sites comprise wells, further wherein the waveguides are single-mode in the vertical dimension and multi-mode in the lateral dimension, and at least one adapter configured to couple with the substrate and provide optical communication between the light source, the waveguides of the substrate, and the detector; packaging; and instructions for use of the system. - View Dependent Claims (56, 57)
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58. A scanning sensor system for detecting a biologically active analyte comprising:
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a light source; a detector; a substrate comprising a plurality of waveguides and a plurality of optical sensing sites in optical communication with one or more of the waveguides, wherein the optical sensing sites comprise wells, further wherein the optical sensing site further comprises a sensor configured to transduce a first light wave generated by the light source in a waveguide, resulting in a second light wave in the same waveguide, the second light wave being detectable by the detector; and at least one adapter configured to couple with the substrate and provide optical communication between the light source, the waveguides of the substrate, and the detector, wherein the plurality of waveguides comprise in-coupling waveguides coupled to out-coupling waveguides by way of combiners, and wherein the first light wave is carried by an in-coupling waveguide and the second light wave is carried by an out-coupling waveguide.
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59. A scanning sensor system for detecting a biologically active analyte comprising:
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a light source; a detector; a substrate comprising a plurality of waveguides and a plurality of optical sensing sites in optical communication with one or more of the waveguides, wherein the optical sensing sites comprise wells, further wherein the waveguides are single-mode in the vertical dimension and multi-mode in the lateral dimension; and at least one adapter configured to couple with the substrate and provide optical communication between the light source, the waveguides of the substrate, and the detector.
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60. A scanning sensor system for detecting a biologically active analyte comprising:
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a light source; a detector; a substrate comprising a plurality of waveguides and a plurality of optical sensing sites in optical communication with one or more of the waveguides, wherein the optical sensing sites comprise wells; and at least one adapter configured to couple with the substrate and provide optical communication between the light source, the waveguides of the substrate, and the detector, wherein the light source is butt-coupled to one or more of the at least one adapter.
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Specification