Heterocyclic receptor agonists for the treatment of diabetes and metabolic disorders

• US 8,288,384 B2
• Filed: 11/16/2009
• Issued: 10/16/2012
• Est. Priority Date: 12/28/2006
• Status: Active Grant

• Current Assignee: CymaBay Therapeutics Inc. (Gilead Sciences Inc.)
• Original Assignee: Metabolex Inc (Gilead Sciences Inc.)
• Inventors: Chen, Xin, Cheng, Peng, Clemens, L. Edward, Johnson, Jeffrey D., Ma, Jingyuan, Murphy, Alison, Nashashibi, Imad, Rabbat, Christoper J., Song, Jiangao, Wilson, Maria E., Zhu, Yan, Zhao, Zuchun
• Primary Examiner(s): Fetterolf, Brandon
• Assistant Examiner(s): Stone, Christopher R
• Application Number:
  US12/619,577
• Publication Number:
  US 20100130511A1
• Time in Patent Office: 1,065 Days
• Field of Search: 514/249
• US Class Current: 514/249
• CPC Class Codes: A61K 31/454 containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
• CPC Class Codes: A61K 31/506 not condensed and containing further heterocyclic rings
• CPC Class Codes: A61P 13/12 of the kidneys
• CPC Class Codes: A61P 27/02 Ophthalmic agents
• CPC Class Codes: A61P 3/00 Drugs for disorders of the metabolism of the blood or the extracellular fluid A61P7/00
• CPC Class Codes: A61P 3/04 Anorexiants; Antiobesity agents
• CPC Class Codes: A61P 3/06 Antihyperlipidemics
• CPC Class Codes: A61P 3/08 for glucose homeostasis pancreatic hormones A61P5/48
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system
• CPC Class Codes: A61P 9/10 for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• CPC Class Codes: A61P 9/12 Antihypertensives
• CPC Class Codes: C07D 277/42 Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
• CPC Class Codes: C07D 401/04 directly linked by a ring-member-to-ring-member bond
• CPC Class Codes: C07D 401/14 containing three or more hetero rings
• CPC Class Codes: C07D 413/04 directly linked by a ring-member-to-ring-member bond
• CPC Class Codes: C07D 413/14 containing three or more hetero rings
• CPC Class Codes: C07D 417/04 directly linked by a ring-member-to-ring-member bond
• CPC Class Codes: C07D 417/14 containing three or more hetero rings

Abstract

Compounds and methods are provided for the treatment of, inter alia, Type II diabetes and other diseases associated with poor glycemic control. The compounds of the invention are orally active.

Claims

1. A method of treating Type II diabetes, said method comprising administering to a subject in need of such treatment an effective amount of a compound that is that is 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine or a pharmaceutically acceptable salt thereof.