Iontophoretic delivery of curcumin and curcumin analogs for the treatment of Alzheimer's disease

• US 8,288,444 B2
• Filed: 06/29/2011
• Issued: 10/16/2012
• Est. Priority Date: 06/27/2008
• Status: Active Grant

• Current Assignee: Codman & Shurtleff Incorporated (Johnson & Johnson)
• Original Assignee: Codman & Shurtleff Incorporated (Johnson & Johnson)
• Inventors: Lilienfeld, Sean, DiMauro, Thomas M
• Primary Examiner(s): WITHERSPOON, SIKARL A
• Application Number:
  US13/172,810
• Publication Number:
  US 20110257587A1
• Time in Patent Office: 475 Days
• Field of Search: 514/681, 514/238.8, 514/551, 604/20
• US Class Current: 514/681
• CPC Class Codes: A61K 31/09 having two or more such linkages
• CPC Class Codes: A61K 31/12 Ketones
• CPC Class Codes: A61K 31/165 having aromatic rings, e.g. colchicine, atenolol, progabide
• CPC Class Codes: A61K 31/216 of acids having aromatic rings, e.g. benactizyne, clofibrate
• CPC Class Codes: A61K 31/22 of acyclic acids, e.g. pravastatin
• CPC Class Codes: A61K 31/221 with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
• CPC Class Codes: A61K 31/223 of alpha-aminoacids
• CPC Class Codes: A61K 9/0009 involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis microelectromechanical systems A61K9/0097
• CPC Class Codes: A61K 9/7023 Transdermal patches and similar drug-containing composite devices, e.g. cataplasms galenical aspects of iontophoretic devices A61K9/0009; microneedle arrays A61K9/0021; buccal patches A61K9/006
• CPC Class Codes: C07C 229/12 to carbon atoms of acyclic carbon skeletons
• CPC Class Codes: C07C 229/34 the carbon skeleton containing six-membered aromatic rings
• CPC Class Codes: C07C 271/54 to carbon atoms of hydrocarbon radicals substituted by carboxyl groups

Abstract

A device for iontophoretically delivering a charged curcuminoid across the skin of an Alzheimer'"'"'s Disease patient.

Claims

1. An iontophoretic drug delivery system comprising:

a) a power source,

b) an anode and a cathode in electrical connection with the power source, and

c) a first electrolyte-containing reservoir in electrical connection with the anode, and

d) a second electrolyte-containing reservoir in electrical connection with the cathode,

wherein one of the reservoirs contains a charged curcuminoid prodrug.

2. The system of claim 1 wherein the charged curcuminoid prodrug comprises a glycinate moiety.

3. The system of claim 1 wherein the curcuminoid comprises bisdemethoxycurcumin.

4. The system of claim 1 wherein the curcuminoid is a hybrid of curcumin and resveratrol.

5. The system of claim 1 wherein the curcuminoid is a hybrid of bisdemethoxycurcumin and resveratrol.

6. The system of claim 1 wherein the curcuminoid is a hybrid of curcumin and 3,3′

,4′

fisetin.

7. The system of claim 1 wherein the curcuminoid is a hybrid of bisdemethoxycurcumin and 3,3′

,4′

fisetin.

8. The system of claim 1 wherein the curcuminoid is a hybrid of curcumin and honokiol.

9. The system of claim 1 wherein the curcuminoid is a hybrid of bisdemethoxycurcumin and honokiol.