Ion trapping

• US 8,288,714 B2
• Filed: 11/11/2010
• Issued: 10/16/2012
• Est. Priority Date: 03/29/2005
• Status: Active Grant

• Current Assignee: Thermo Finnigan LLC (Thermo Fisher Scientific Incorporated)
• Original Assignee: Thermo Finnigan LLC (Thermo Fisher Scientific Incorporated)
• Inventors: Makarov, Alexander A., Denisov, Eduard V., Jung, Gerhard, Malek, Robert, Lange, Oliver
• Primary Examiner(s): Souw, Bernard E
• Assistant Examiner(s): SMYTH, ANDREW P
• Application Number:
  US12/944,357
• Publication Number:
  US 20110057099A1
• Time in Patent Office: 705 Days
• Field of Search: None
• US Class Current: 250/283
• CPC Class Codes: H01J 49/004 Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
• CPC Class Codes: H01J 49/423 with radial ejection
• CPC Class Codes: H01J 49/425 with a logarithmic radial electric potential, e.g. orbitraps
• CPC Class Codes: H01J 49/4295 Storage methods

Abstract

This invention relates to a method of trapping ions and to an ion trapping assembly. In particular, the present invention has application in gas-assisted trapping of ions in an ion trap prior to a mass analysis of the ions in a mass spectrometer. The invention provides a method of trapping ions in a target ion trap of an ion trapping assembly that comprises a series of volumes arranged such that ions can traverse from one volume to the next, the volumes including the target ion trap, whereby ions are allowed to pass repeatedly through the volumes such that they also pass into and out from the target ion trap without being trapped. Potentials may be used to reflect the ions from respective ends of the ion trapping assembly. Optionally, a potential well and/or gas-assisted cooling may be used to cause the ions to settle in the target ion trap.

Claims

1. A method of trapping and reacting ions in a target ion trap comprising:

introducing ions of a first type into an ion trapping assembly comprising a series of volumes arranged such that the ions of the first type can traverse from one volume to the next, the volumes including the target ion trap and a second volume;

allowing the ions of the first type to pass into and out from the target ion trap without being trapped;

causing the ions of the first type passing out from the target ion trap to enter the second volume, to be reflected from an end of the second volume, and to pass out of the second volume without being trapped in the second volume;

guiding the ions of the first type passing out of the second volume such that they pass into the target ion trap for a second time;

introducing ions of a second type into the target ion trap, the ions of the second type having a polarity opposite to the polarity of the ions of the first type;

simultaneously confining the ions of the first and second types within the target ion trap; and

allowing the ions of the first and second types to mix.

2. The method of claim 1, wherein the step of simultaneously confining the ions includes generating a pseudo-potential.

3. The method of claim 2, wherein the step of generating a pseudo-potential includes applying RF voltages to electrodes of the target ion trap.

4. The method of claim 3, wherein the RF voltages are applied to lenses positioned at opposite ends of the target ion trap.

5. The method of claim 1, further comprising steps of:

establishing a first DC potential well to confine the ions of the first type within a first portion of the target ion trap;

establishing a second DC potential well to confine the ions of the second type within a second portion of the target ion trap, the first and second portions being spatially separated; and

wherein the step of allowing the ions of the first and second types to mix includes removing the first and second DC potential wells.

6. The method of claim 2, wherein the pseudo-potential is generated after the ions of the first and second types have been introduced into the target ion trap.

7. The method of claim 2, wherein the pseudo-potential is generated along the longitudinal axis of the target ion trap.