Method of utilizing an implant for targeting external beam radiation

• US 8,288,745 B2
• Filed: 04/28/2008
• Issued: 10/16/2012
• Est. Priority Date: 10/10/1997
• Status: Active Grant

• Current Assignee: Senorx Incorporated (Becton, Dickinson & Co)
• Original Assignee: Senorx Incorporated (Becton, Dickinson & Co)
• Inventors: Corbitt, John, Anthony, Lorl
• Primary Examiner(s): LOGIE, MICHAEL J
• Application Number:
  US12/110,748
• Publication Number:
  US 20080281388A1
• Time in Patent Office: 1,632 Days
• Field of Search: 250/515.1, 250/492.1, 600/1, 600/2, 607/108, 623/7, 623/8, 623/23.75, 606/77, 424/400
• US Class Current: 250/515.1
• CPC Class Codes: A61B 2090/3908 Soft tissue, e.g. breast tissue
• CPC Class Codes: A61B 2090/3966 Radiopaque markers visible in an X-ray image
• CPC Class Codes: A61B 90/39 Markers, e.g. radio-opaque or breast lesions markers
• CPC Class Codes: A61F 2/12 Mammary prostheses and implants
• CPC Class Codes: A61F 2250/0098 radio-opaque, e.g. radio-opaque markers
• CPC Class Codes: A61N 2005/1061 using an x-ray imaging system having a separate imaging source
• CPC Class Codes: A61N 5/10 X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy A61N5/01 takes precedence
• CPC Class Codes: A61N 5/1049 for verifying the position of the patient with respect to the radiation beam

Abstract

A novel method of partial breast radiation utilizing a breast implant which can provide a stable and improved target for stereotactic radiation treatment.

Claims

1. A method of partial breast radiation therapy comprising the steps of:

placing within a breast cavity a substantially radio-opaque implant constructed of biocompatible and biodegradable material, said substantially radio-opaque implant supporting the tissue surrounding the breast cavity; and

directing a radiation beam to said substantially radio-opaque implant serving as a target for delivery of radiation therapy to margins around the breast cavity, such that the radiation beam does not materially irradiate the whole of the breast.

2. The method of claim 1, wherein the radiation therapy is delivery of a therapeutically effective dosage of radiation to said breast tissue surrounding the implant via a stereotactic radiation machine.

3. The method of claim 2, wherein the radiation therapy is delivery of multiple therapeutically effective dosages of radiation to said breast tissue surrounding the implant in a single treatment via a stereotactic radiation machine.

4. The method of claim 2, wherein the radiation therapy is delivery of therapeutically effective dosages of radiation to said breast tissue surrounding the implant multiple times in a single treatment via a stereotactic radiation machine.

5. The method of claim 2 further comprising the step of initiating targeting of a radiation beam for delivery of radiation therapy occurs about 1-90 days subsequent placement of the implant.

6. The method of claim 1, wherein the radiation therapy is delivery of a therapeutically effective dosage of radiation to said breast tissue surrounding the implant via multidirectional radiation therapy.

7. The method of claim 6 further comprising the step of initiating targeting of a radiation beam for delivery of radiation therapy occurs about 1-90 days subsequent placement of the implant.

8. The method of claim 1, wherein the radiation therapy is delivery of a therapeutically effective dosage of radiation to said breast tissue surrounding the implant via image guided radiation therapy.

9. The method of claim 8 further comprising the step of initiating targeting of a radiation beam for delivery of radiation therapy occurs about 1-90 days subsequent placement of the implant.

10. The method of claim 1, wherein the radiation therapy is delivery of a therapeutically effective dosage of radiation to said breast tissue surrounding the implant via 3-D conformal radiation therapy.

11. The method of claim 10 further comprising the step of initiating targeting of a radiation beam for delivery of radiation therapy occurs about 1-90 days subsequent placement of the implant.

12. The method of claim 1, wherein the radiation therapy is delivery of a therapeutically effective dosage of radiation to said breast tissue surrounding the implant via intensity modulated radiation therapy.

13. The method of claim 1, wherein the breast cavity is a lumpectomy cavity, and further comprising the step of aspirating air from the lumpectomy cavity at any time after placement of the implant.

14. The method of claim 1 further comprising the step of initiating targeting of a radiation beam for delivery of radiation therapy occurs about 1-90 days subsequent placement of the implant.

15. The method of claim 1 further comprising the steps of initiating chemotherapy and thereafter, initiating targeting of a radiation beam for delivery of radiation therapy occurs up to 120 days subsequent placement of the implant.

16. The method of claim 1, wherein said substantially radio-opaque implant has a shape selected to guide the delivery of radiation therapy to the margins around said breast cavity.

17. The method of claim 1, wherein said substantially radio-opaque implant is constructed of a porous material.

18. A method of partial breast radiation comprising the steps of:

placing within a breast lumpectomy cavity an implant constructed of biocompatible and biodegradable material with a substantially radio-opaque marker contained within the implant, and said implant supporting the tissue surrounding the breast lumpectomy cavity; and

directing a radiation beam to said implant, said substantially radio-opaque marker within said implant serving as a target for delivery of radiation therapy to margins around the breast cavity, such that the radiation beam does not materially irradiate the whole of the breast.

19. The method of claim 18, wherein the radiation therapy is delivery of a therapeutically effective dosage of radiation to said breast tissue surrounding the implant or marker via a stereotactic radiation machine.

20. The method of claim 18, wherein the radiation therapy is delivery of multiple therapeutically effective dosages of radiation to said breast tissue surrounding the implant or marker in a single treatment via a stereotactic radiation machine.

21. The method of claim 18, wherein the radiation therapy is delivery of a therapeutically effective dosage of radiation to said breast tissue surrounding the implant or marker via multidirectional radiation therapy.

22. The method of claim 18, wherein the radiation therapy is delivery of a therapeutically effective dosage of radiation to said breast tissue surrounding the implant or marker via image guided radiation therapy.

23. The method of claim 18, wherein the radiation therapy is delivery of a therapeutically effective dosage of radiation to said breast tissue surrounding the implant or marker via 3-D conformal radiation therapy.

24. The method of claim 18, wherein the radiation therapy is delivery of a therapeutically effective dosage of radiation to said breast tissue surrounding the implant or marker via intensity modulated radiation therapy.

25. The method of claim 18 further comprising the step of aspirating air from the breast lumpectomy cavity at any time after placement of the implant.

26. The method of claim 18 further comprising the step of initiating targeting of a radiation beam for delivery of radiation therapy occurs about 1-90 days subsequent placement of the implant.

27. The method of claim 18 further comprising the step of initiating targeting of a radiation beam for delivery of radiation therapy occurs about 1-90 days subsequent placement of the implant.

28. The method of claim 18 further comprising the steps of initiating chemotherapy and thereafter, initiating targeting of a radiation beam for delivery of radiation therapy occurs up to 120 days subsequent placement of the implant.

29. The method of claim 18, wherein said implant has a shape selected to guide the delivery of radiation therapy to the margins around said breast lumpectomy cavity.

30. The method of claim 18, wherein the substantially radio-opaque marker is a radio-opaque element centrally located within said implant, said radio-opaque element being constructed from a material different from the material from which said implant is constructed.