Systems for measuring properties of a physiological fluid suspension

• US 8,289,514 B2
• Filed: 03/05/2009
• Issued: 10/16/2012
• Est. Priority Date: 03/05/2008
• Status: Active Grant

• Current Assignee: Aggredyne, Inc.
• Original Assignee: Aggredyne, Inc.
• Inventors: Sukavaneshvar, Sivaprasad, Teitel, Edward R., Mohammad, Syed F.
• Primary Examiner(s): Ton, Tri T
• Application Number:
  US12/398,480
• Publication Number:
  US 20090225316A1
• Time in Patent Office: 1,321 Days
• Field of Search: 356335-343, 356 39- 42, 356426-428, 250/547, 250/222.2
• US Class Current: 356/337
• CPC Class Codes: G01F 1/74 Devices for measuring flow of a fluid or flow of a fluent solid material in suspension in another fluid
• CPC Class Codes: G01N 21/49 within a body or fluid
• CPC Class Codes: G01N 21/53 within a flowing fluid, e.g. smoke
• CPC Class Codes: G01N 33/4905 Determining clotting time of blood by chemical methods G01N33/86, C12Q1/54
• CPC Class Codes: G01N 33/86 involving blood coagulating time or factors, or their receptors

Abstract

A method of evaluating a property of a physiological fluid suspension comprises measuring a value of the property of a liquid portion of the physiological fluid suspension via light scattering, and comparing the measured value with a reference value to evaluate the property of the liquid portion of the physiological fluid suspension.

Claims

1. A method of evaluating a property of a liquid portion of a physiological fluid suspension, comprising:

establishing a baseline value for the property of the liquid portion of the physiological fluid suspension;

inducing a change in the physiological fluid suspension;

measuring a changed value for the property of the physiological fluid suspension; and

comparing the baseline value with the changed value to evaluate the property of the liquid portion,

wherein at least one of the baseline value and the changed value are measured when the physiological fluid suspension is in motion, and wherein the motion is recirculated flow.

2. The method of claim 1, at least one of the steps of i) establishing the baseline value, and measuring the changed value, is carried out via light scattering.

3. The method of claim 1, further comprising calculating a rate of change of the property of the liquid portion of the physiological fluid suspension.

4. The method of claim 3, wherein calculating the rate of change of the property of the liquid portion is based upon a time elapsed in reaching the changed value of the property.

5. The method of claim 1, wherein the physiological fluid suspension is selected from the group consisting of whole blood, platelet suspensions, leukocyte suspensions, red blood cell suspensions, blood plasmas, blood plasma components, protein solution, protein suspensions, suspension of modified proteins, suspension of cells, suspension of modified cells, suspension of particulates and combinations thereof.

6. The method of claim 2, wherein the physiological fluid suspension includes platelets, and platelet aggregates of the physiological fluid suspension are used as optical markers for the light scattering.

7. The method of claim 2, wherein the physiological fluid suspension includes blood cells, and blood cells of the physiological fluid suspension are used as optical markers for the light scattering.

8. The method of claim 2, wherein the physiological fluid suspension includes extraneous particulates added thereto, and the extraneous particulates added to the physiological fluid suspension are used as optical markers for the light scattering.

9. The method of claim 8, wherein the extraneous particulates include microspheres or nanoparticles.

10. The method of claim 2, wherein one or more features external to the physiological fluid suspension is used as an optical markers for the light scattering.

11. The method of claim 1, wherein both the baseline value and the changed value are measured when the physiological fluid suspension is in motion.

12. The method of claim 1, wherein the baseline value is established when the fluid is stationary and wherein the changed value is measured when the fluid is in motion.

13. The method of claim 1, wherein the baseline value is measured when the fluid is in motion and wherein the changed value is measured when the fluid is stationary.

14. The method of claim 1, wherein the property to be evaluated is the ability of the physiological fluid suspension to clot.

15. The method of claim 1, wherein the property to be evaluated is a viscosity of the liquid portion of the physiological fluid suspension.

16. The method of claim 1, wherein the property to be evaluated is a turbidity of the liquid portion of the physiological fluid suspension.

17. The method of claim 1, wherein the property to be evaluated is a distribution of constituents in the physiological fluid suspension.

18. The method of claim 1, wherein the property to be evaluated is a color of one or more constituents of the physiological fluid suspension.

19. The method of claim 1, wherein the property to be evaluated is an increase or a decrease in viscosity of the liquid portion of the physiological fluid suspension.