Methods and apparatus for enhanced fiducial point determination and non-invasive hemodynamic parameter determination

• US 8,290,577 B2
• Filed: 08/21/2007
• Issued: 10/16/2012
• Est. Priority Date: 03/23/2007
• Status: Active Grant

• Current Assignee: FUJIFILM SonoSite, Inc. (Fujifilm Holdings Corporation)
• Original Assignee: FUJIFILM SonoSite, Inc. (Fujifilm Holdings Corporation)
• Inventors: Brooks, Donald J., Malecha, Jeremy
• Primary Examiner(s): Bertram, Eric D.
• Assistant Examiner(s): Dinga, Roland
• Application Number:
  US11/894,989
• Publication Number:
  US 20080234594A1
• Time in Patent Office: 1,883 Days
• Field of Search: 600/513, 600/510, 600/484, 600/509, 600/506, 600/526, 600/393, 600/521, 600/528
• US Class Current: 600/513
• CPC Class Codes: A61B 5/0004 characterised by the type of physiological signal transmitted
• CPC Class Codes: A61B 5/0006 ECG or EEG signals
• CPC Class Codes: A61B 5/02028 Determining haemodynamic parameters not otherwise provided for, e.g. cardiac contractility or left ventricular ejection fraction
• CPC Class Codes: A61B 5/318 Heart-related electrical modalities, e.g. electrocardiography [ECG]
• CPC Class Codes: A61B 5/352 Detecting R peaks, e.g. for synchronising diagnostic apparatus; Estimating R-R interval
• CPC Class Codes: A61B 5/683 Means for maintaining contact with the body A61B5/6802 takes precedence
• CPC Class Codes: A61B 5/726 using Wavelet transforms
• CPC Class Codes: A61B 7/00 Instruments for auscultation
• CPC Class Codes: A61B 7/04 Electric stethoscopes microphones, acoustic transducers therefor H04R

Abstract

Methods and apparatus for utilizing multiple sources of physiologic data to enhance measurement robustness and accuracy. In one embodiment, phonocardiography or “heart sounds” data is used in combination with one or more other techniques (for example, impedance cardiography or ICG waveforms, and/or electrocardiography or ECG waveforms) to provide more accurate and robust physiological and/or hemodynamic assessment of living subjects. In one variant, the aforementioned methods and apparatus are used to improve ICG fiducial point (e.g., B, C and X point) detection and identification accuracy. Moreover, the new ICG fiducial points that may be clinically important may be identified using the disclosed methods and apparatus. In a further aspect, the invention discloses methods and apparatus for utilization of ICG and/or ECG waveform information to improve the identification and characterization of heart sounds (such as e.g., S1, S2, S3, or S4 heart sounds), murmurs, and other such artifacts or phenomena.

Claims

1. A computer-implemented method of assessing cardiac function within a living subject, comprising:

obtaining;

(i) acoustic information relating to the cardiac system of said subject, the acoustic information including a heart sound;

(ii) electrocardiographic (ECG) information relating to said subject; and

(iii) impedance cardiographic (ICG) information relating to said subject;

using the ECG information to validate a timing of the heart sound of the acoustic information so as to provide a validated sound event of the acoustic information;

using the validated sound event of the acoustic information to detect a fiducial point of the ICG information; and

utilizing said acoustic, ECG and ICG information substantially in concert to assess cardiac function.

2. The method of claim 1, wherein said act of obtaining acoustic and ECG information are utilized to improve ICG fiducial point detection in said obtained ICG information.

3. The method of claim 2, further comprising:

confirming the timing of cardiac sounds within said obtained acoustic information utilizing at least in part a portion of said obtained ECG information; and

detecting one or more ICG fiducial points utilizing at least in part the confirmed timing within said obtained acoustic information.

4. The method of claim 3, wherein said cardiac sounds comprise S1 and S2 heart sounds.

5. The method of claim 4, wherein said one or more ICG fiducial points comprises a “

B”

point and a “

X”

point in said obtained ICG information.

6. The method of claim 3, wherein said portion of said ECG information comprises an “

R”

point reference.

7. The method of claim 1, wherein said acoustic and ECG information are utilized to improve classification of a plurality of ICG waveforms.

8. The method of claim 1, wherein said obtained ECG and ICG information are utilized to improve the characterization of said acoustic information.

9. The method of claim 1, further comprising:

disposing a sensor apparatus on the thoracic cavity of the living subject, said sensor apparatus comprising a plurality of terminals and an acoustic receptor device.

10. The method of claim 9, wherein said acts of obtaining acoustic and ECG information are utilized to improve ICG fiducial point detection.

11. The method of claim 10, further comprising:

confirming the timing of cardiac sounds within said obtained acoustic information utilizing at least in part a portion of said ECG information; and

detecting one or more ICG fiducial points in said obtained ICG information utilizing at least in part the confirmed timing within said obtained acoustic information.

12. The method of claim 9, wherein said steps of obtaining acoustic and ECG information are utilized to improve classification of a plurality of ICG waveforms.

13. The method of claim 9, wherein said steps of obtaining ECG and ICG information are utilized to improve the characterization of said obtained acoustic information.

14. The method of claim 1, further comprising:

utilizing a duration of at least a portion of said acoustic information relative to a duration of a QRS complex duration obtained from said ECG information.

15. The method of claim 14, wherein said duration of at least a portion of said acoustic information comprises determining a duration of cardiac sounds from an onset point to a termination point of a particular sound.

16. The method of claim 14, further comprising identifying one or more ICG fiducial points in said obtained ICG information by utilizing, at least in part, said duration.

17. The method of claim 1, further comprising:

disposing a sensor apparatus on the thoracic cavity of the living subject; and

optimizing at least one pacemaker setting based at least in part on said assessment of cardiac function.

18. The method of claim 17, wherein said sensor apparatus comprises a plurality of electrically conductive terminals and an acoustic receptor device.

19. The method of claim 17, wherein said at least one pacemaker setting comprises a setting for AV or VV timing.

20. The method of claim 1, further comprising:

disposing a sensor apparatus on the thoracic cavity of a living subject;

beginning a course of treatment for said subject; and

utilizing subsequently obtained acoustic, ECG, and ICG information to assess cardiac function resulting from said treatment.

21. The method of claim 1, further comprising:

evaluating the heart sound so as to provide an unvalidated sound event of the acoustic information;

segregating the unvalidated sound event from the validated sound event; and

using the unvalidated sound event to detect another fiducial point of the ICG information.

22. A computer-implemented method of assessing cardiac function within a living subject, comprising:

obtaining acoustic information relating to the cardiac system of said subject, the acoustic information including a heart sound;

obtaining electrocardiographic (ECG) signals relating to said subject; and

obtaining impedance cardiographic (ICG) signals relating to said subject;

converting said acoustic information into electrical acoustic signals, and providing said acoustic, ECG, and ICG signals to a processing device;

using the ECG signals to validate a timing of the heart sound of the acoustic information so as to provide a validated sound event of the acoustic information;

using the validated sound event of the acoustic information to detect a fiducial point of the ICG signals; and

utilizing said acoustic, ECG and ICG signals to form a profile of the cardiac function of said living subject.

23. The method of claim 22, wherein said acoustic signals are provided to said processing device over a conductor, said conductor also carrying said ICG and ECG electrical signals to said processing device.

24. The method of claim 22, wherein said processing device comprises a digital processor, and said method further comprising converting said acoustic, ECG and ICG signals from an analog domain to a digital domain.

25. The method of claim 22, wherein said acoustic signals are provided to said processing device over a wireless data link.

26. The method of claim 22, wherein said acoustic signals are transported to a component remote from said living subject, and subsequently converted into electrical signals.

27. The method of claim 22, further comprising:

utilizing said obtained acoustic and ECG signals to uniquely characterize at least portions of an ICG waveform; and

separating said characterized portions into at least two different classifications.

28. The method of claim 27, wherein said separation is performed by a signal processing algorithm.

29. The method of claim 27, wherein said separation is performed manually by a user, said manual separation being accomplished via at least a graphical user interface.

30. The method of claim 22, further comprising:

evaluating the heart sound so as to provide an unvalidated sound event of the acoustic information;

segregating the unvalidated sound event from the validated sound event; and

using the unvalidated sound event to detect another fiducial point of the ICG signals.

31. A computer-implemented method of assessing cardiac regurgitation within a living subject, comprising:

obtaining acoustic information relating to the cardiac system of said subject, the acoustic information including a heart sound;

obtaining electrocardiographic (ECG) information relating to said subject; and

obtaining impedance cardiographic (ICG) information relating to said subject;

using the ECG information to validate a timing of the heart sound of the acoustic information so as to provide a validated sound event of the acoustic information;

using the validated sound event of the acoustic information to detect a fiducial point of the ICG information; and

utilizing said acoustic, ECG and ICG information collectively to assess cardiac regurgitation within said subject.

32. The method of claim 31, wherein said acts of obtaining acoustic and ECG information are utilized at least in part to determine a location within the subject'"'"'s heart of said regurgitation.

33. The method of claim 31, further comprising:

evaluating the heart sound so as to provide an unvalidated sound event of the acoustic information;

segregating the unvalidated sound event from the validated sound event; and

using the unvalidated sound event to detect another fiducial point of the ICG information.

34. A computer-implemented method of assessing quality of cardiac data obtained from a living subject, comprising:

obtaining acoustic information relating to the cardiac system of said subject, the acoustic information including a heart sound;

obtaining electrocardiographic (ECG) information relating to said subject;

obtaining impedance cardiographic (ICG) information relating to said subject;

using the ECG information to validate a timing of the heart sound of the acoustic information so as to provide a validated sound event of the acoustic information;

using the validated sound event of the acoustic information to detect a fiducial point of the ICG information; and

utilizing said acoustic, ECG and ICG information to assess the quality of one or more cardiac beats.

35. The method of claim 34, further comprising:

evaluating the heart sound so as to provide an unvalidated sound event of the acoustic information;

segregating the unvalidated sound event from the validated sound event; and

using the unvalidated sound event to detect another fiducial point of the ICG information.