Incubator for babies before implantation

• US 8,292,798 B2
• Filed: 10/16/2006
• Issued: 10/23/2012
• Est. Priority Date: 06/08/2004
• Status: Active Grant

• Current Assignee: Eurica Califorrniaa
• Original Assignee: Eurica Califorrniaa
• Inventors: Califorrniaa, Eurica
• Primary Examiner(s): LACYK, JOHN P
• Application Number:
  US11/549,972
• Publication Number:
  US 20080097143A1
• Time in Patent Office: 2,199 Days
• Field of Search: 600 33- 35, 600 21- 22, 128897-898, 435/7.2, 435/29, 435/366, 435/373, 435/374, 435/325, 435/288.4, 435/288.5, 435/297.5, 435/305.2, 435/305.3
• US Class Current: 600/33
• CPC Class Codes: A01N 1/02 Preservation of living parts
• CPC Class Codes: A01N 1/0263 Non-refrigerated containers specially adapted for transporting or storing living parts whilst preserving, e.g. cool boxes, blood bags or "straws" for cryopreservation
• CPC Class Codes: A61B 17/435 for embryo or ova transplantation
• CPC Class Codes: A61G 11/00 Baby-incubators; Couveuses
• CPC Class Codes: B01L 3/5027 by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip B01L3/5023 takes precedence; micromixers B01F33/30; microreactors for synthesis B01J19/0093; microcapillary devices in general B81B1/00
• CPC Class Codes: C12M 21/06 for in vitro fertilization
• CPC Class Codes: C12M 25/00 Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
• CPC Class Codes: C12M 29/04 Filters; Permeable or porous membranes or plates, e.g. dialysis
• CPC Class Codes: C12M 41/14 Incubators; Climatic chambers per se B01L1/00

Abstract

The invention relates to an incubator for babies. It is of special value for the treatment of premature infants as an intensive care unit at any time during life from creation to implantation. A cradle is sided with ports to enable fluidic ventilation. Advantageously the incubator includes an optical path for imaging the patient via a clear bottom and open top. The incubator is provided with easy access and various accessories required for an intensive care unit.

Claims

1. An incubator for babies before implantation, comprising:

a layer-based microfluidic enclosure designed to maintain a human embryo or hatchling as a patient in a controlled environment for medical care,

the enclosure, having a flooring and a surrounding wall structure with an open top, forming a cradle support for the patient, and having a microfluidic ventilation system to provide a flow of incubation liquid media in and out of the enclosure, wherein the enclosure is further characterized as being assembled from a plurality of layers bonded together and populated with at least one patient care device;

the layers, including at least one layer forming the flooring, at least one other layer forming the wall structure by means of a hole disposed completely therethrough, and a ventilation network of microfluidic channels or vias disposed in one or more layers in fluidic communication with the enclosure;

the at least one patient care device, including a microfluidic device for urging fluid in the ventilation network; and

,

the microfluidic ventilation system, including the microfluidic device and the associated ventilation network to provide the patient in the cradle support with gentle, fluidic ventilation.

2. The incubator of claim 1 further including means of a temperature bath to maintain predetermined incubator temperatures, including a predetermined temperature of the incubation liquid media ventilating the patient in the cradle support, the bath, comprising a running fluid urged at a preset bath temperature through a bath network of housings formed by channels, vias, coils, a double-walled vessel, a jacketing system, or a bed in thermal contact with the incubator, wherein the bath network is separate from the ventilation network and which bath network communicates thermally but not fluidically with the incubation liquid media ventilating the patient in the cradle support.

3. The incubator of claim 2, wherein the flooring comprises an optical glass layer 170 microns thick with a refractive index of 1.515 to enable conformity with high resolution microscopy techniques employing an inverted microscope to monitor the patient in the cradle support via a vertical path for optics.

4. The incubator of claim 3 further including a MEMS-actuated cover for the enclosure to provide a means of closure for the open top in case of a need for closure.

5. The incubator of claim 1 further including a volume-sensing device to detect volume changes in the incubation liquid media covering the patient in the enclosure, wherein the microfluidic device is responsive to the volume-sensing device to adjust the flow in and out of the enclosure to maintain predetermined volumes of the incubation liquid media in the enclosure.

6. The incubator of claim 1, wherein the flooring comprises a material which permits the passage of infrared radiation.

7. The incubator of claim 2, wherein the layers are made of glass.

8. The incubator of claim 7, wherein the glass layers are bonded together adhesivelessly.

9. The incubator of claim 8, wherein the hole forming the enclosure walls is 500 microns in diameter or 500 microns square and the wall structure has a layer height of 100 or 150 microns.

10. The incubator of claim 1, wherein the microfluidic ventilation system is adapted to adjusting a rate of flow of the incubation liquid media over the patient to maintain an optimal rate of flow-related heat dissipation for an endogenous heat of the patient in reference to a reading of patient temperature acquired by means of patient thermometry.

11. The incubator of claim 2, wherein the temperature bath means is adapted to adjusting the temperature of the incubation liquid media to maintain an optimal ambient temperature for the patient in reference to a reading of patient temperature acquired by means of patient thermometry.

12. The incubator of claim 2, wherein the flooring, being formed of clear layers, provides an optical path into the incubator for viewing, measuring, or illuminating the patient or other incubator interest by means of an optical technique.

19. The incubator of claim 7 further including thermal barriers or voids disposed in the flooring or walls of the enclosure as thermal insulation to thermally isolate the patient in the cradle support in a manner of double-walled incubator construction.

20. The incubator of claim 12 further including a microlens formed in the flooring or attached thereto.

13. An incubator for a baby before implantation, comprising:

a flooring to support the baby, liquid media to cover and incubate the baby, a microfluidic system to circulate the liquid media at a predetermined temperature and flow rate to provide the baby with fluidic ventilation and thermoregulatory support, and a volume-sensing device to detect a volume of the liquid media, wherein the microfluidic system is adapted to maintaining the volume of the liquid media covering the baby within a predetermined range of volumes based on feedback from the volume-sensing device.

14. The incubator of claim 13, wherein the liquid media covering the baby is a microdrop.

15. The incubator of claim 14, wherein the volume-sensing device comprises a beam of light from a light source and a photodetector array, the beam of light being directed through a meniscus of the microdrop in a lens fashion and detected by the photodetector array, whereby changes in a lens shape of the meniscus cause the light beam to be focused on corresponding points on the photodetector array as an indicator of microdrop volume.

16. An incubator for a baby before implantation, comprising:

an enclosure having a flooring to support the baby, an open top and at least one sidewall, liquid media to cover and incubate the baby, and a microfluidic system to circulate the liquid media to provide the baby with fluidic ventilation in the enclosure, the sidewall having at least one ventilation port disposed therein through which the liquid media are urged by the microfluidic system to fluidically ventilate the baby in the enclosure, wherein the sidewall is formed by at least one layer bonded to the flooring by means of layer-based microfabrication and includes microfluidic channels or vias disposed therein, the ventilation port of the sidewall being formed by at least one of the microfluidic channels to provide horizontal flow or at least one of the microfluidic vias to provide vertical flow in or out of the enclosure.

17. The incubator of claim 16, wherein at least one sidewall provides flow into the enclosure and at least one sidewall provides flow out of the enclosure.

18. The incubator of claim 16, wherein the flooring contains at least one ventilation port in fluidic communication with the ventilation port of the sidewall to circulate the liquid media in and out of the enclosure by means of the microfluidic system.