Systems and methods for determining a substantially hematocrit independent analyte concentration
First Claim
1. A method of determining a substantially hematocrit-independent concentration of an analyte in a fluid sample deposited on a test strip having a reference electrode and a working electrode, in which the working electrode is coated with a reagent layer, the method comprising:
- applying a fluid sample to the test strip for a reaction period;
applying a first test voltage to the reference electrode and the working electrode and measuring a first current value therebetween, the first test voltage being an absolute value from about 100 millivolts to about 600 millivolts;
applying a first rest voltage between the reference electrode and the working electrode, the first rest voltage is an absolute value from about zero to about 50 millivolts;
applying a second test voltage between the reference electrode and the working electrode and measuring a second current value, in which the second test voltage is an absolute value from about 100 millivolts to about 600 millivolts;
applying a second rest voltage between the reference electrode and the working electrode, in which the second rest voltage is an absolute value from about zero to about 50 millivolts;
applying a third test voltage between the reference electrode and the working electrode and measuring a third current value, in which the third test voltage is an absolute value from about 100 millivolts to about 600 millivolts; and
calculating substantially hematocrit-independent concentration of the analyte from the first, second and third current values, in which the calculating comprises calculating the substantially hematocrit-independent concentration of the analyte from the y-intercept of a graph representing log10(Ii) versus log10(time);
where;
Ii is the current value measured near the end of each test voltage and i ranges from about 1 to about 3; and
time is the time at which Ii is measured.
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Accused Products
Abstract
A method and system is provided to allow for determination of substantially Hematocrit independent analyte concentration. In one example, an analyte measurement system is provided that includes a test strip and a test meter. The test strip includes a reference electrode and a working electrode, in which the working electrode is coated with a reagent layer. The test meter includes an electronic circuit and a signal processor. The electronic circuit applies a plurality of voltages to the reference electrode and the working electrode over respective durations. The signal processor is configured to determine a substantially hematocrit-independent concentration of the analyte from a plurality of current values as measured by the processor upon application of a plurality of test voltages to the reference and working electrodes over a plurality of durations interspersed with rest voltages lower than the test voltages being applied to the electrodes.
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Citations
6 Claims
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1. A method of determining a substantially hematocrit-independent concentration of an analyte in a fluid sample deposited on a test strip having a reference electrode and a working electrode, in which the working electrode is coated with a reagent layer, the method comprising:
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applying a fluid sample to the test strip for a reaction period; applying a first test voltage to the reference electrode and the working electrode and measuring a first current value therebetween, the first test voltage being an absolute value from about 100 millivolts to about 600 millivolts; applying a first rest voltage between the reference electrode and the working electrode, the first rest voltage is an absolute value from about zero to about 50 millivolts; applying a second test voltage between the reference electrode and the working electrode and measuring a second current value, in which the second test voltage is an absolute value from about 100 millivolts to about 600 millivolts; applying a second rest voltage between the reference electrode and the working electrode, in which the second rest voltage is an absolute value from about zero to about 50 millivolts; applying a third test voltage between the reference electrode and the working electrode and measuring a third current value, in which the third test voltage is an absolute value from about 100 millivolts to about 600 millivolts; and calculating substantially hematocrit-independent concentration of the analyte from the first, second and third current values, in which the calculating comprises calculating the substantially hematocrit-independent concentration of the analyte from the y-intercept of a graph representing log10(Ii) versus log10(time); where; Ii is the current value measured near the end of each test voltage and i ranges from about 1 to about 3; and time is the time at which Ii is measured. - View Dependent Claims (2, 3, 4, 5, 6)
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Specification