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Sustained release intraocular implants and methods for preventing retinal dysfunction

  • US 8,293,210 B2
  • Filed: 10/29/2007
  • Issued: 10/23/2012
  • Est. Priority Date: 04/30/2004
  • Status: Expired due to Term
First Claim
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1. A method of treating an ocular condition in an eye of a patient, comprising the step of placing an extruded, rod-shaped biodegradable intraocular implant in an eye of the patient, the implant comprising about 40% w/w brimonidine freebase and a biodegradable polymer matrix that releases an amount of brimonidine freebase effective to reduce a symptom of the ocular condition,wherein the implant is placed in the posterior of the eye;

  • wherein the biodegradable polymer matrix comprises a 1;

    1 mixture of first and second biodegradable polymers;

    wherein the first biodegradable polymer is a poly (D,L-lactide) polymer having an average molecular weight of about 14,000 daltons; and

    wherein the second biodegradable polymer is a 50;

    50 poly (D,L-lactide-coglycolide) copolymer having an average molecular weight of about 11,700 daltons.

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