Variant form of urate oxidase and use thereof
First Claim
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1. A pharmaceutical composition comprising:
- (a) an isolated uricase comprising an amino acid sequence of SEQ ID NO. 7; and
(b) a pharmaceutically acceptable carrier;
wherein the uricase is conjugated with a polymer.
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Abstract
The present invention relates to genetically modified proteins with uricolytic activity. More specifically, the invention relates to proteins comprising truncated urate oxidases and methods for producing them, including PEGylated proteins comprising truncated urate oxidases.
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Citations
16 Claims
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1. A pharmaceutical composition comprising:
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(a) an isolated uricase comprising an amino acid sequence of SEQ ID NO. 7; and (b) a pharmaceutically acceptable carrier; wherein the uricase is conjugated with a polymer. - View Dependent Claims (3, 4, 5, 6, 7, 8, 9, 10)
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2. A pharmaceutical composition comprising:
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(a) a uricase comprising an amino acid sequence of SEQ ID NO. 8; and (c) a pharmaceutically acceptable carrier (b) wherein the uricase is conjugated with a polymer.
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11. A method for preparing a pharmaceutical composition for reducing uric acid levels in a biological fluid of a subject in need thereof, comprising:
- (a) preparing a conjugate of the uricase of SEQ ID NO;
7 with a polymer; and
(b) adding the uricase conjugate to a pharmaceutically acceptable carrier. - View Dependent Claims (13, 15)
- (a) preparing a conjugate of the uricase of SEQ ID NO;
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12. A method for preparing a pharmaceutical composition for reducing uric acid levels in a biological fluid of a subject in need thereof, comprising:
- (a) preparing a conjugate of the uricase of SEQ ID NO;
8 with a polymer; and
(b) adding the uricase conjugate to a pharmaceutically acceptable carrier. - View Dependent Claims (14, 16)
- (a) preparing a conjugate of the uricase of SEQ ID NO;
Specification