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Materials and methods for prevention and treatment of RNA viral diseases

  • US 8,293,717 B2
  • Filed: 12/15/2009
  • Issued: 10/23/2012
  • Est. Priority Date: 04/30/2002
  • Status: Expired due to Fees
First Claim
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1. A method of inhibiting an RNA virus infection in a patient, comprising administering to the patient:

  • (a) a nucleotide sequence encoding at least one enzymatically active fragment of a 2′

    -5′

    oligoadenylate synthetase, wherein the nucleotide sequence is expressed in the patient;

    or (b) at least one enzymatically active fragment of a 2′

    -5′

    oligoadenylate synthetase;

    wherein the RNA virus is a type that transiently produces double-stranded RNA during intermediate replication; and

    wherein the enzymatically active fragment of (a) and (b) comprises between 5 and 42 amino acids of SEQ ID NO;

    2, SEQ ID NO;

    4, SEQ ID NO;

    6, SEQ ID NO;

    8, SEQ ID NO;

    10, or SEQ ID NO;

    12;

    or the enzymatically active fragment comprises at least 43 amino acids of SEQ ID NO;

    2, SEQ ID NO;

    4, SEQ ID NO;

    6, SEQ ID NO;

    8, SEQ ID NO;

    10, or SEQ ID NO;

    12.

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