Spectral analysis for a more reliable determination of physiological parameters

• US 8,295,901 B2
• Filed: 02/16/2007
• Issued: 10/23/2012
• Est. Priority Date: 02/20/2006
• Status: Expired due to Fees

• Current Assignee: Fraunhofer Gesellschaft Zur Foerderung Der Angewandten Forsching E.V.
• Original Assignee: Fraunhofer Gesellschaft Zur Foerderung Der Angewandten Forsching E.V.
• Inventors: Tobola, Andreas, Vogl, Ulrich, Moersdorf, Hans-Joachim
• Primary Examiner(s): Winakur, Eric
• Assistant Examiner(s): Liu, Chu Chuan (JJ)
• Application Number:
  US11/676,190
• Publication Number:
  US 20080027299A1
• Time in Patent Office: 2,076 Days
• Field of Search: 600/310, 600/322, 600/323, 600/316, 600/324, 600/326, 600/331, 600/473, 600/476, 600/517, 708/446, 708/520
• US Class Current: 600/323
• CPC Class Codes: A61B 5/02416 using photoplethysmograph signals, e.g. generated by infrared radiation A61B5/14552 takes precedence
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61B 5/7207 of noise induced by motion artifacts
• CPC Class Codes: A61B 5/7257 using Fourier transforms

Abstract

An apparatus for determining a spectral ratio between a first signal having a first spectrum which depends on a biological quantity, and a second signal having a second spectrum which depends on a biological quantity, the first signal and the second signal having a plurality of harmonics of a periodic signal, the apparatus including a computer for computing a first wave ratio between a spectral value of the first spectrum which has a frequency of a harmonic of the plurality of harmonics, and a spectral value of the second spectrum which has the frequency of the harmonic; and for computing a second wave ratio between a spectral value of the first spectrum which has a frequency of another harmonic of the plurality of harmonics, and a spectral value of the second spectrum which has the frequency of the other harmonic. In addition, the apparatus includes an optimizer.

Claims

1. An apparatus for determining a spectral ratio between a first signal comprising a first spectrum which depends on a biological quantity, and a second signal comprising a second spectrum which depends on a biological quantity, the first signal and the second signal comprising a plurality of harmonics of a periodic signal, the apparatus comprising:

a computer for computing a first wave ratio between a spectral value of the first spectrum at a first frequency which comprises a harmonic of the plurality of harmonics, and a spectral value of the second spectrum at the first frequency;

and for computing a second wave ratio between a spectral value of the first spectrum at a second frequency which comprises another harmonic of the plurality of harmonics, and a spectral value of the second spectrum at the second frequency;

an optimizer for determining the spectral ratio while using the first and second wave ratios, the optimizer being adapted to determine the spectral ratio such that it differs from the first wave ratio and the second wave ratio, and meets an optimization criterion,

wherein the computer is adapted to pass on a plurality of the spectral values of the two spectra to the optimizer as tuples of a frequency,

wherein the spectral values are complex spectral values,

wherein the optimizer is adapted to determine a regression line from the plurality of tuples of the complex spectral values, the actual or perpendicular square distance from the tuples to the regression line being minimized as the optimization criterion, and

wherein the optimizer is adapted to determine the regression line by applying the total least squares fit method, and the spectral ratio depends on the regression line.

2. The apparatus as claimed in claim 1, wherein the period of the periodic signal is independent of the biological quantity.

3. The apparatus as claimed in claim 1, wherein the first signal and the second signal depend on the biological quantity in different ways.

4. The apparatus as claimed in claim 1, wherein the first and second signals exhibit dependencies on the biological quantity in the plurality of harmonics.

5. The apparatus as claimed in claim 1, wherein the biological quantity is a blood oxygen saturation or a heart frequency.

6. The apparatus as claimed in claim 1, wherein the computer is adapted to compute the first wave ratio at a fundamental wave frequency of the periodic signal, and the second wave ratio at a harmonic frequency of the periodic signal.

7. The apparatus as claimed in claim 1, wherein the computer is adapted to form wave ratios between a plurality of spectral values of the first and second signals, and wherein, in addition, the optimizer is adapted to form the spectral ratio from the plurality of wave ratios.

8. The apparatus as claimed in claim 1, wherein the signals originate from a transillumination of a tissue of a test person.

9. The apparatus as claimed in claim 1, wherein one signal is based on an infrared light receive signal, and one signal is based on a red light receive signal.

10. The apparatus as claimed in claim 1, wherein the optimizer is adapted to optimize a cumulated distance measure between the spectral ratio and the wave ratios.

11. The apparatus as claimed in claim 1, wherein the optimizer is adapted to determine the regression line using a singular-value decomposition of a matrix, the two signals forming the columns of the matrix, and that singular value which is smaller, in magnitude, of the singular-value decomposition being set to zero for linearizing the equation system.

12. The apparatus as claimed in claim 1, further comprising a provider for providing the first and second signals, and further being adapted to reduce frequency portions on the basis of previous knowledge of the spectral curve of a signal portion.

13. The apparatus as claimed in claim 12, wherein the provider for providing the first and second signals is adapted to reduce other spectral portions on the basis of known intensity ratios between the harmonics.

14. The apparatus as claimed in claim 12, wherein the provider for providing the first and second signals is adapted to provide only spectral portions of the fundamental wave, of the first harmonic, and of the second harmonic of the periodic signal.

15. The apparatus as claimed in claim 12, wherein the provider for providing the first and second signals is adapted to provide only those signal portions of signals which correspond to a pulse signal of a living being in terms of their frequency and amplitude ratios.

16. The apparatus as claimed in claim 12, wherein the provider for providing the first and second signals is adapted to determine, on the basis of a reference spectrum, pulse signal portions of a living being, and to mask out other frequencies from the signals.

17. The apparatus as claimed in claim 1, wherein the computer is adapted to pass the signals on to the optimizer, and wherein the optimizer is adapted to determine, on the basis of the spectra of the signals, a reference spectrum for which a distance measure in relation to the spectra of the signals is optimized.

18. The apparatus as claimed in claim 1, wherein the two signals originate from a plethysmogram.

19. The apparatus as claimed in claim 1, comprising a second provider for providing a first time-discrete reference signal which exhibits a first interference portion, and a second time-discrete reference signal which exhibits a second interference portion, the second interference portion being shifted in phase relative to the first interference portion;

and a subtractor for generating a differential signal from the two reference signals, the differential signal comprising a frequency component being caused by the first and second interference portions, and

a manipulator for manipulating the two signals, on the basis of the differential signal, such that the frequency component is reduced in a manipulated signal; and

the manipulated time-discrete signal is made available to the computer.

20. The apparatus as claimed in claim 1, comprising a first provider for providing the time-discrete signal, the provider being adapted to sample an iterating optical signal which corresponds to a bright period during which a transmit light source adopts an on state, and comprising a second provider for providing a time-discrete reference signal adapted to sample two optical signals which correspond to dark periods during which no transmit light source adopts an on state.

21. The apparatus as claimed in claim 1, comprising a first provider for providing a time-discrete signal, the provider being adapted to process an iterating optical signal, the optical signal comprising sequences and comprising a sequence of at least two bright periods during which a transmit light source adopts an on state, and comprising at least one dark period during which no transmit light source adopts the on state, and wherein the at least two bright periods are irregularly arranged within a sequence, and the provider for providing the time-discrete signal further being adapted to make available the time-discrete signal in accordance with a bright transmit signal on the basis of the information about the arrangement of the bright periods in the sequence.

22. The apparatus as claimed in claim 21, wherein the sequence of an optical signal is based on a clock, in accordance with which the bright and dark periods occur.

23. The apparatus as claimed in claim 22, wherein the provider for providing the time-discrete signals are adapted to operate at a clock higher than 800 Hz.

24. The apparatus as claimed in claim 1, wherein the signals originate from a spread spectrum modulation.

25. A method for determining a spectral ratio between a first signal comprising a first spectrum which depends on a biological quantity, and a second signal comprising a second spectrum which depends on a biological quantity, the first signal and the second signal comprising a plurality of harmonics of a periodic signal, the method comprising:

computing a first wave ratio between a spectral value of the first spectrum at a first frequency which comprises a harmonic of the plurality of harmonics, and a spectral value of the second spectrum at the first frequency;

computing a second wave ratio between a spectral value of the first spectrum at a second frequency which comprises another harmonic of the plurality of harmonics, and a spectral value of the second spectrum at the second frequency;

determining the spectral ratio while using the first and second wave ratios, the spectral ratio being determined such that it differs from the first and second wave ratios and meets an optimization criterion,

wherein the step of determining comprises;

passing on a plurality of the spectral values of the two spectra as tuples of a frequency, and

wherein the spectral values are complex spectral values,

computing a regression line from the plurality of tuples of the complex spectral values, the actual or perpendicular square distance from the tuples to the regression line being minimized as the optimization criterion, wherein the regression line is determined in accordance with the total least squares fit method, and the spectral ratio depends on the regression line.