Hemodynamic waveform-based diagnosis and treatment

• US 8,298,150 B2
• Filed: 09/13/2006
• Issued: 10/30/2012
• Est. Priority Date: 01/11/2000
• Status: Active Grant

• Current Assignee: Cedars-Sinai Medical Center (Cedars Sinai Health System)
• Original Assignee: Cedars-Sinai Medical Center (Cedars Sinai Health System)
• Inventors: Mann, Brian, Whiting, James S., Eigler, Neal L.
• Primary Examiner(s): Natnithithadha, Navin
• Application Number:
  US11/520,454
• Publication Number:
  US 20070088223A1
• Time in Patent Office: 2,239 Days
• Field of Search: 600/481, 600483-485, 600/486, 600/488, 600/508, 600/509, 600/513
• US Class Current: 600/485
• CPC Class Codes: A61B 2560/0223 of calibration, e.g. protocols for calibrating sensors
• CPC Class Codes: A61B 5/0215 by means inserted into the body catheters A61M25/00
• CPC Class Codes: A61B 5/02156 Calibration means
• CPC Class Codes: A61B 5/283 Invasive
• CPC Class Codes: A61B 5/349 Detecting specific parameters of the electrocardiograph cycle
• CPC Class Codes: A61B 5/7267 involving training the classification device
• CPC Class Codes: A61B 8/04 Measuring blood pressure
• CPC Class Codes: A61N 1/36521 the parameter being derived from measurement of an electrical impedance
• CPC Class Codes: A61N 1/36564 controlled by blood pressure

Abstract

A method of monitoring pressure within a medical patient, includes measuring an actual pressure in a medical patient in a first time period; measuring an indicator of the actual pressure in the first time period, wherein the indicator is derived from an electrical signal of the patient'"'"'s heart; determining a correlative relationship between the actual pressure and the indicator, wherein both the actual pressure and the indicator are obtained in the first time period; measuring the indicator in a second time period; and determining the actual pressure in the second time period based on the correlative relationship obtained in the first time period and the indicator obtained in the second time period.

Claims

1. A method of monitoring pressure within a medical patient, comprising:

measuring an actual pressure in a medical patient in a first time period;

measuring an indicator of said actual pressure in the first time period, wherein said indicator is derived from an electrical signal of the patient'"'"'s heart;

determining by electronic hardware, a correlative relationship between the actual pressure and the indicator, wherein both the actual pressure and the indicator are obtained in the first time period;

measuring the indicator in a second time period; and

determining the actual pressure in said second time period based on the correlative relationship obtained in said first time period and the indicator obtained in said second time period.

2. The method of claim 1, wherein the indicator is selected from a group consisting of one or more of the following:

an echocardiogram waveform, and an IEGM waveform.

3. The method of claim 1, wherein the correlative relationship is based at least in part on at least one of an amplitude and a timing parameter of the indicator, wherein said indicator is an electrocardiogram signal.

4. The method of claim 1, wherein the correlative relationship comprises an artificial neural network.

5. The method of claim 1, wherein said determining is performed within the medical patient.

6. The method of claim 1, wherein the electronic hardware comprises a processor.

7. The method of claim 1, wherein the measuring an actual pressure, an indicator of said actual pressure, and the indicator in a second time period, and the determining the actual pressure are implemented by the electronic hardware.

8. The method of claim 1, wherein the measuring an indicator of said actual pressure is implemented with an electrode.

9. A method of monitoring pressure within a medical patient, comprising:

measuring an indicator of a pressure within a medical patient, wherein the indicator is related to an electrical signal generated by the patient;

determining by electronic hardware the pressure based at least in part upon the indicator and a pre-determined relationship between the pressure and the indicator, wherein the pre-determined relationship is determined from historical pressure data and historical indicator data of the patient; and

providing an indication of the pressure.

10. The method of claim 9, wherein at least one of said historical pressure data and said historical indicator data comprises data from only said medical patent.

11. The method of claim 9, wherein the electronic hardware comprises a processor.

12. The method of claim 9, wherein the measuring an indicator of a pressure and providing an indication of the pressure are implemented by the electronic hardware.

13. The method of claim 9, wherein the measuring an indicator of a pressure is implemented with an electrode.