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Flow-induced delivery from a drug mass

  • US 8,298,176 B2
  • Filed: 07/19/2010
  • Issued: 10/30/2012
  • Est. Priority Date: 06/09/2006
  • Status: Active Grant
First Claim
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1. A method, comprising:

  • implanting a reservoir into a human or other animal, the reservoir containing a mass of a solid form of a drug that is sparingly water-soluble;

    passing vehicle from a source past the solid drug mass so as to entrain drug from the mass; and

    delivering the passed vehicle and entrained drug to a target tissue in the human or other animal, and wherein the solid form of the drug is a basic form and the vehicle includes an acid at a concentration that is substantially the same as a predetermined desired therapeutically-effective concentration.

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