Systems for removing dimethyl sulfoxide (DMSO) or related compounds, or odors associated with same

• US 8,298,320 B2
• Filed: 05/02/2011
• Issued: 10/30/2012
• Est. Priority Date: 09/12/2005
• Status: Active Grant

• Current Assignee: Abela Pharmaceuticals, Inc.
• Original Assignee: Abela Pharmaceuticals, Inc.
• Inventors: Cozean, Colette
• Primary Examiner(s): LAWRENCE JR, FRANK M
• Application Number:
  US13/099,098
• Publication Number:
  US 20110203584A1
• Time in Patent Office: 547 Days
• Field of Search: 951/35, 951/37, 951/41, 128/206.12, 128/203.29, 128/205.27, 128/205.25, 128/206.21, 128/205.26, 423/244.01
• US Class Current: 95/135
• CPC Class Codes: A41D 13/1115 with a horizontal pleated pocket
• CPC Class Codes: A41D 13/1123 with a duckbill configuration
• CPC Class Codes: A41D 13/1192 with antimicrobial agent
• CPC Class Codes: A61L 9/014 containing sorbent material, e.g. activated carbon
• CPC Class Codes: A61M 16/0087 Environmental safety or protection means, e.g. preventing explosion
• CPC Class Codes: A61M 16/0093 by adsorption, absorption or filtration
• CPC Class Codes: A61M 16/06 Respiratory or anaesthetic masks
• CPC Class Codes: A61M 16/105 Filters A61M16/047, A61M16/22 take precedence; water traps A61M16/08
• CPC Class Codes: A61M 16/1055 bacterial
• CPC Class Codes: A61M 16/1065 in the expiratory path
• CPC Class Codes: A61M 16/1075 by influencing the temperature A61M16/1045 takes precedence
• CPC Class Codes: A61M 16/208 Non-controlled one-way valves, e.g. exhalation, check, pop-off non-rebreathing valves
• CPC Class Codes: A61M 2205/7527 liquophilic, hydrophilic
• CPC Class Codes: A62B 23/00 Filters for breathing-protection purposes gas-filters in general B01D
• CPC Class Codes: B01D 2253/202 Polymeric adsorbents
• CPC Class Codes: B01D 2253/311 Porosity, e.g. pore volume
• CPC Class Codes: B01D 2257/306 Organic sulfur compounds, e.g. mercaptans
• CPC Class Codes: B01D 2257/90 Odorous compounds not provided for in groups B01D2257/00 - B01D2257/708
• CPC Class Codes: B01D 2257/91 Bacteria; Microorganisms
• CPC Class Codes: B01D 2259/4533 for medical purposes
• CPC Class Codes: B01D 2259/4541 : for portable use, e.g. gas masks
• CPC Class Codes: B01D 53/02 : by adsorption, e.g. preparative gas chromatography solid sorbent compositions B01J20/00, preparation of inorganic compounds or elements C01
• CPC Class Codes: B01D 53/04 : with stationary adsorbents B01D53/025 takes precedence
• CPC Class Codes: B01D 53/508 : by treating the gases with solids
• CPC Class Codes: B01J 20/28085 : being more than 50 nm, i.e. macropores

Abstract

Preferred embodiments of the invention relate to systems for removing dimethyl sulfoxide (DMSO) or related compounds, or odors associated with same. The systems include adsorbents, odor adsorbing fabrics, masks, clean air members and clean air supply assemblies.

Claims

1. A method for reducing the undesired odor associated with one or more metabolites of dimethyl sulfoxide (DMSO), comprising:

transporting, via a medical ventilator, DMSO metabolite-containing air comprising one or more DMSO metabolites through said medical ventilator in use by a subject that has been treated with DMSO,

wherein said medical ventilator comprises a first filter comprising a chemical odor removal layer and a HEPA filter,

wherein the ventilator is configured to receive said DMSO metabolite-containing air,

wherein the first filter comprises an adsorbent configured to adsorb said one or more DMSO metabolites from said DMSO metabolite-containing air,

wherein said adsorbent comprises activated carbon, and

capturing an amount of said one or more DMSO metabolites sufficient to reduce the associated odor by contacting said DMSO metabolite-containing air with said first filter, thereby decreasing the concentration of said one or more DMSO metabolites passing through said ventilator.

2. The method of claim 1, wherein said DMSO metabolite-containing air comprises one or more of methylsulfonylmethane (MSM) or dimethyl sulfide (DMS or methylthiomethane).

3. The method of claim 1, wherein said chemical odor removal layer comprises one or more of citric acid, chitosan, and MSM.

4. The method of claim 3, wherein said chemical odor removal layer comprises MSM and said DMSO metabolite-containing air comprises MSM.

6. The method of claim 1 or claim 5, wherein said HEPA filter further comprises an indicator compound.

7. The method of claim 1 or claim 5, further comprising passing said DMSO metabolite-containing air through an additional odor control agent selected from the group consisting of one or more of the following:

zeolites, silicates, activated carbons, diatomaceous earth, cyclodextrine, clay, chelating agents, ion exchange resins, perfumes and mixture thereof.

5. A method for reducing the undesired odor associated with one or more metabolites of DMSO, comprising:

transporting, via a medical ventilator, DMSO metabolite-containing air comprising one or more DMSO metabolites through said medical ventilator in use by a subject that has been treated with DMSO,

wherein said medical ventilator comprises a first filter and a HEPA filter,

wherein said first filter further comprises an indicator compound,

wherein the ventilator is configured to receive said DMSO metabolite-containing air,

wherein the first filter comprises an adsorbent configured to adsorb said one or more DMSO metabolites from said DMSO metabolite-containing air,

wherein said adsorbent comprises activated carbon, and

capturing an amount of said one or more DMSO metabolites sufficient to reduce the associated odor by contacting said DMSO metabolite-containing air with said first filter, thereby decreasing the concentration of said one or more DMSO metabolites assin throu h said ventilator.

8. A method for providing air having a reduced undesired odor associated with one or more metabolites of dimethyl sulfoxide (DMSO) comprising:

conveying air comprising one or more DMSO metabolites having an undesired odor through a clean air member comprising;

an adsorbent configured to adsorb said one or more DMSO metabolites or the odor associated therewith;

a pre-filter;

and a HEPA filter, and

trapping an amount of said one or more DMSO metabolites or the odor associated therewith sufficient to reduce the associated odor by contacting said DMSO metabolites with said adsorbent, said pre-filter, and said HEPA filter to thereby provide air having a reduced undesired odor associated with one or more metabolites of DMSO.

9. The method of claim 8, wherein said one or more metabolites of DMSO are from an individual being treated with DMSO.

10. The method of claim 8, wherein said one or more metabolites of DMSO are from the environmental degradation of DMSO.

11. The method of claim 8, wherein said member is connected to the ductwork of a HVAC system.

12. A method for reducing undesired odors associated with one or more metabolites of dimethyl sulfoxide (DMSO) in the vicinity of a patient that has been treated with DMSO comprising:

positioning said patient within a patient isolation unit coupled to a clean air supply assembly, said clean air supply assembly comprising;

a first adsorbent configured to adsorb said one or more DMSO metabolites or the odor associated therewith;

a pre-filter; and

a HEPA filter, and

said patient isolation unit comprising an odor-absorbing fabric article comprising a second adsorbent configured to adsorb said one or more DMSO metabolites or the odor associated therewith,

conveying DMSO metabolite-containing air from said patient through said patient isolation unit;

reducing the concentration of said one or more DMSO metabolites sufficient to reduce the associated odor by contacting said DMSO metabolite-containing air with said first adsorbent, said pre-filter, and said HEPA filter, thereby providing air having reduced undesired odors associated with said one or more metabolites of DMSO; and

positioning said odor-absorbing fabric article comprising said second adsorbent around said patient,

wherein said odor-absorbing fabric article comprising said adsorbent further reduces said one or more DMSO metabolites or the odor associated therewith.

13. The method of claim 12, wherein said first adsorbent comprises activated charcoal particles and said second adsorbent is selected from the group consisting of one or more of the following:

chitosan, chitosan salt, crosslinked chitosan and a mixture thereof.

14. The method of claim 12, further comprising positioning said patient on bedding comprising an adsorbent configured to adsorb said one or more DMSO metabolites or the odor associated therewith.

15. The method of claim 14, wherein said bedding comprises a liquid pervious topsheet;

a backsheet; and

an absorbent core intermediate between said backsheet and said topsheet.

16. The method of claim 15, wherein said absorbent core comprises

a cationic polysaccharide comprising an aminopolysaccharide selected from the group consisting of one or more of the following:

chitosan, chitosan salt, crosslinked chitosan and a mixture thereof;

an acidic pH buffering means having a pH in the range of from about 3.5 to about 6.5; and

an absorbent gelling material.

17. The method of claim 12, wherein said odor-absorbing fabric article is dimensioned to encompass the patient'"'"'s upper torso or the entire patient bed area while still allowing caregiver access to the patient'"'"'s upper torso.

18. The method of claim 17, wherein said odor-absorbing fabric article comprises polyester fibers optionally intertwined with cellulosic wood pulp fibers.