Preparations and methods for ameliorating or reducing presbyopia

• US 8,299,079 B2
• Filed: 12/20/2010
• Issued: 10/30/2012
• Est. Priority Date: 05/22/2009
• Status: Active Grant

• Current Assignee: Visus Therapeutics, Inc.
• Original Assignee: Hek Development, LLC
• Inventors: Kaufman, Herbert E.
• Primary Examiner(s): Padmanabhan, Sreeni
• Assistant Examiner(s): Ramachandran, Uma
• Application Number:
  US12/973,479
• Publication Number:
  US 20110152274A1
• Time in Patent Office: 680 Days
• Field of Search: 514/249, 514/397, 514/393, 514/235.8
• US Class Current: 514/249
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/27 of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
• CPC Class Codes: A61K 31/325 Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof thiurams A61K31/145
• CPC Class Codes: A61K 31/498 Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 9/0048 Eye, e.g. artificial tears
• CPC Class Codes: A61P 27/02 Ophthalmic agents
• CPC Class Codes: A61P 27/10 for accommodation disorders, e.g. myopia

Abstract

This application relates to the use of one or more parasympathomimetic drugs in combination with one or more alpha agonists to create optically beneficial miosis to, for example, temporarily treat presbyopia. The invention provides a pharmaceutical preparation comprising a therapeutically effective amount of one or more parasympathomimetic drugs or cholinesterase inhibitors, or a pharmaceutically acceptable salt thereof, in combination with one or more alpha agonists or antagonists, or a pharmaceutically acceptable salt thereof. The invention further provides for a method for treating, ameliorating or reducing presbyopia of a patient having an eye, comprising administering to said eye a pharmaceutically effective amount of the ophthalmic preparation.

Claims

1. A method for ameliorating or reducing presbyopia of a patient having an eye, comprising administering to said eye a therapeutically effective amount of an ophthalmic topical preparation comprising a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof, in an amount of 0.25-1.0% and brimonidine, or a pharmaceutically acceptable salt thereof in an amount of 0.05-0.2%.

2. The method of claim 1, wherein pilocarpine is present in an amount of 1% and brimonidine is present in an amount of 0.20%.

3. A method of producing ocular miosis in a subject under normal light conditions which comprises administering to the subject an amount of an ophthalmic preparation comprising a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof, in an amount of 0.25-1.0% and brimonidine, or pharmaceutically acceptable salts thereof, in an amount of 0.05-0.2% effective to produce ocular miosis.

4. A method of ameliorating, reducing or eliminating dimness of vision of a patient having an eye comprising administering to said eye a therapeutically effective amount of an ophthalmic preparation comprising a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof, in an amount of 0. 25-1.0% and brimonidine or a pharmaceutically acceptable salt thereof in an amount of 0.05-0.2%.

5. A method of improving focus and/or correcting refractive errors of a patient having an eye comprising administering to said eye a therapeutically effective amount of an ophthalmic preparation comprising a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof, in an amount of 0. 25-1.0% and brimonidine, or pharmaceutically acceptable salts thereof in an amount of 0.05-0.2%.

6. A method of treating presbyopia in a patient in need of treatment thereof comprising administering an effective amount of an ophthalmic topical preparation comprising a therapeutically effective amount pilocarpine, or a pharmaceutically acceptable salt thereof, in an amount of 0.25-1.0% and brimonidine, or a pharmaceutically acceptable salt thereof in an amount of 0.05-0.2%. to a single eye of a patient thereby leaving the other eye untreated.