Autonomous, ambulatory analyte monitor or drug delivery device
First Claim
1. An analyte monitoring device operable to draw a fluid sample from a subject, the device comprising:
- a plurality of microneedles disposed on a carrier,a plurality of microchannels defined as openings in said carrier, wherein each of the plurality of microneedles is at least intermittently in fluid communication with a corresponding microchannel, wherein each of the plurality of microneedles is connected to and moveable with a corresponding fluidic capture site and is constructed and arranged to collect the fluid sample from the subject, wherein the corresponding fluidic capture site is configured to fluidly couple to and deliver the fluid sample to at least one of the plurality of microchannels, and wherein each microchannel is associated with a reagent,at least one actuator operable to extend each microneedle and corresponding fluidic capture site to collect the fluid sample from the subject and to deliver the fluid sample to the at least one of the plurality of microchannels, anda controller operable to initiate analyte testing of the fluid sample.
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Accused Products
Abstract
The invention relates to analyte monitoring/drug (pharmaceutical agent) delivery device. The invention is suited for monitoring various blood constituents such as glucose. The device has a housing that at least partially encloses a plurality of microneedles disposed on a carrier and an electronics portion. Each microneedle is in fluid communication with a corresponding microchannel. Each microneedle is individually addressable. That is, each microneedle can be extended and retracted individually via an actuator. The electronics portion includes a processor and associated circuitry (e.g., memory, supporting electronics and the like), a motor or the like, a sensor, a power supply (e.g., battery) and optionally an interface. In general, the processor controls the operation of the device and is data communication with the actuator, motor, sensor and interface. The invention provides for autonomous operation, that is, without intervention of the user. The invention can optionally provide for calibration without intervention of the user. The invention can also provide for semi-continuous monitoring for day and night time. The invention can provide for up to four, or more, weeks of operation. The invention can provide for a device that is relative small in size, and therefore unobtrusive. The invention can also provide for device with remote control and interactive electronics. The invention may be also used for the delivery of various pharmaceutical agents including high potency drugs to minimize patient intervention and minimize discomfort.
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Citations
24 Claims
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1. An analyte monitoring device operable to draw a fluid sample from a subject, the device comprising:
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a plurality of microneedles disposed on a carrier, a plurality of microchannels defined as openings in said carrier, wherein each of the plurality of microneedles is at least intermittently in fluid communication with a corresponding microchannel, wherein each of the plurality of microneedles is connected to and moveable with a corresponding fluidic capture site and is constructed and arranged to collect the fluid sample from the subject, wherein the corresponding fluidic capture site is configured to fluidly couple to and deliver the fluid sample to at least one of the plurality of microchannels, and wherein each microchannel is associated with a reagent, at least one actuator operable to extend each microneedle and corresponding fluidic capture site to collect the fluid sample from the subject and to deliver the fluid sample to the at least one of the plurality of microchannels, and a controller operable to initiate analyte testing of the fluid sample. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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Specification