Artificial venous valve containing therapeutic agent
First Claim
Patent Images
1. An implantable valve prosthesis comprising:
- a frame having compressed and expanded configurations, the frame comprising an exterior wall and a frame segment having an axial length, the exterior wall defining a hollow interior space surrounded by the exterior wall and extending continuously through the frame segment along the axial length, the exterior wall further defining at least one aperture defining a conduit extending through the exterior wall to the hollow interior space;
a valve member operatively connected to the exterior wall and having first and second opposing sides and first and second opposing ends, the first side, second side, and second end being continuously attached to the frame by being wrapped around and surrounding a portion of the frame that includes the frame segment such that the hollow interior space and the at least one aperture are positioned under the wrapped portion of the frame, the first end being free of the frame, the valve member adapted to modify fluid flow through a body lumen; and
a therapeutic agent loaded in the hollow interior space in such a way so that at least a portion thereof may pass through the at least one aperture and the valve member.
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Accused Products
Abstract
The invention relates to a prosthetic valve for regulating flow through a body lumen and delivering a therapeutic agent into said lumen. In one embodiment, the prosthesis includes a frame having an exterior wall, a hollow interior space, a valve member, and at least one aperture through the exterior wall that permits a controlled amount of therapeutic agent loaded into the hollow interior into the surrounding body lumen following implantation. In another embodiment, the prosthesis includes a frame having a groove, a valve member, and therapeutic agent loaded in the groove.
62 Citations
20 Claims
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1. An implantable valve prosthesis comprising:
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a frame having compressed and expanded configurations, the frame comprising an exterior wall and a frame segment having an axial length, the exterior wall defining a hollow interior space surrounded by the exterior wall and extending continuously through the frame segment along the axial length, the exterior wall further defining at least one aperture defining a conduit extending through the exterior wall to the hollow interior space; a valve member operatively connected to the exterior wall and having first and second opposing sides and first and second opposing ends, the first side, second side, and second end being continuously attached to the frame by being wrapped around and surrounding a portion of the frame that includes the frame segment such that the hollow interior space and the at least one aperture are positioned under the wrapped portion of the frame, the first end being free of the frame, the valve member adapted to modify fluid flow through a body lumen; and a therapeutic agent loaded in the hollow interior space in such a way so that at least a portion thereof may pass through the at least one aperture and the valve member. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification