Prevention and treatment of oxidative stress disorders by glutathione and phase II detoxification enzymes

• US 8,303,949 B2
• Filed: 07/25/2008
• Issued: 11/06/2012
• Est. Priority Date: 12/18/2001
• Status: Active Grant

• Current Assignee: Brassica Foundation for Chemoprotection Research, Inc.
• Original Assignee: Brassica Foundation for Chemoprotection Research, Inc.
• Inventors: Gao, Xiangqun, Dinkova-Kostova, Albena T., Talalay, Paul
• Primary Examiner(s): Saidha, Tekchand
• Application Number:
  US12/179,986
• Publication Number:
  US 20090017002A1
• Time in Patent Office: 1,565 Days
• Field of Search: 424/94.4, 435/183
• US Class Current: 424/94.4
• CPC Class Codes: A61K 31/00 Medicinal preparations containing organic active ingredients
• CPC Class Codes: A61K 31/26 Cyanate or isocyanate esters; Thiocyanate or isothiocyanate esters
• CPC Class Codes: A61K 31/7024 Esters of saccharides
• CPC Class Codes: A61P 17/18 Antioxidants, e.g. antiradicals preparations for protection against sunlight A61Q17/00
• CPC Class Codes: A61P 25/28 for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• CPC Class Codes: A61P 27/02 Ophthalmic agents
• CPC Class Codes: A61P 39/06 Free radical scavengers or antioxidants
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

The present invention generally relates to the field of treating oxidative stress disorders by administering a pharmaceutically effective amount of a compound that elevates the intracellular levels of glutathone or intracelluar levels of at least one Phase II detoxification enzyme in animal tissue. The present invention also relates to the field of protecting a subject from oxidative stress disorders by administering a pharmaceutically effective amount of a compound that elevates the intracellular levels of glutathone or intracelluar levels of at least one Phase II detoxification enzyme in the subject. The present invention also relates to a pharmaceutical composition useful for the treatment of oxidative stress disorders.

Claims

1. A method of protecting a subject from photooxidation consisting of administering to the subject an effective amount of a compound that elevates intracellular levels of glutathione or intracellular levels of at least one Phase II detoxification enzyme in a tissue of said subject, wherein the compound is selected from the group consisting of an isothiocyanate and a glucosinolate.

2. The method of claim 1, wherein the subject'"'"'s tissue is skin.

3. The method of claim 1, wherein the subject'"'"'s tissue is an eye.

4. The method of claim 1, wherein photooxidation causes skin cancer.

5. The method of claim 1, wherein the compound is formulated as a composition for topical administration, and the composition further comprises a carrier or excipient.

6. The method of claim 5, wherein the composition is a lotion, a cream, a gel or an ointment.

7. The method of claim 1, wherein said isothiocyanate is sulforaphane.

8. The method of claim 1, wherein said Phase II detoxification enzyme is quinone reductase.