Thiazolidinedione analogues for the treatment of metabolic diseases

• US 8,304,441 B2
• Filed: 11/16/2011
• Issued: 11/06/2012
• Est. Priority Date: 09/14/2007
• Status: Active Grant

• Current Assignee: Cirius Therapeutics, Inc.
• Original Assignee: Metabolic Solutions Development Company, LLC
• Inventors: Colca, Gerard R., Gadwood, Robert C., Parker, Tim
• Primary Examiner(s): Shameem, Golam M M
• Assistant Examiner(s): Cheng, Karen
• Application Number:
  US13/279,657
• Publication Number:
  US 20120129896A1
• Time in Patent Office: 356 Days
• Field of Search: 514/369, 548/183
• US Class Current: 514/369
• CPC Class Codes: A61K 31/426 1,3-Thiazoles
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics

Abstract

The present invention relates to thiazolidinedione analogues that are useful for treating hypertension, diabetes, and inflammatory diseases.

Claims

1. A method of treating diabetes comprising administering to a patient in need thereof a compound selected from

2. The method of claim 1, wherein the diabetes being treated is type-2 diabetes.

3. The method of claim 1, wherein the diabetes being treated is type-1 diabetes.

4. A method of treating diabetes comprising administering to a patient in need thereof a pharmaceutical composition comprising a compound selected from

5. The method of claim 4, wherein the pharmaceutical composition further comprises a DPP-4 inhibitor.

6. The method of claim 5, wherein the DPP-4 inhibitor is selected from sitagliptin, vildagliptin, or any combination thereof.

7. The method of claim 4, wherein the pharmaceutical composition further comprises a GLP-1 agonist, a GLP-2 agonist, or any combination thereof.

8. The method of claim 4, wherein the pharmaceutical composition further comprises a statin.

9. The method of claim 8, wherein the statin is selected from atorvastatin, cerivastatin, fluvastatin, lovastatin, mevastatin, simvastatin, rosuvastatin, pravastatin, or any combination thereof.