Resorbable nanoenhanced hemostatic structures and bandage materials

• US 8,304,595 B2
• Filed: 12/05/2008
• Issued: 11/06/2012
• Est. Priority Date: 12/06/2007
• Status: Expired due to Fees

• Current Assignee: Nanosys Incorporated (Shoei Electronic Materials, Inc.)
• Original Assignee: Nanosys Incorporated (Shoei Electronic Materials, Inc.)
• Inventors: Daniels, R. Hugh, Dubrow, Robert S., Enzerink, Robert, Li, Esther, Sahi, Vijendra, Goldman, Jay L., Parce, J. Wallace
• Primary Examiner(s): Bianco, Patricia
• Assistant Examiner(s): HAWTHORNE, OPHELIA ALTHEA
• Application Number:
  US12/329,431
• Publication Number:
  US 20090192429A1
• Time in Patent Office: 1,432 Days
• Field of Search: 602/1, 602/41, 602/48, 602/52, 602/43, 424443-449, 428/292.1, 427/2.31, 977/712, 977/722, 977/742, 977/762, 977/902
• US Class Current: 602/43
• CPC Class Codes: A61B 17/0057 Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect sutures A61B17/04; closing rectum or urethra near body surface A61F2/0009
• CPC Class Codes: A61B 17/064 Surgical staples, i.e. penetrating the tissue
• CPC Class Codes: A61B 2017/00601 Implements entirely comprised between the two sides of the opening
• CPC Class Codes: A61B 2017/00884 enhancing wound closure
• CPC Class Codes: A61B 2017/00893 pharmaceutically effective
• CPC Class Codes: A61F 13/00991 for treating webs, e.g. for moisturising, coating, impregnating or applying powder
• CPC Class Codes: A61F 13/01008 characterised by the material
• CPC Class Codes: A61F 13/01034 characterised by a property
• CPC Class Codes: A61F 13/36 Surgical swabs, e.g. for absorbency or packing body cavities during surgery A61F13/38 takes precedence
• CPC Class Codes: A61F 2013/00472 with chemical means
• CPC Class Codes: A61F 2013/0054 for deep wounds
• CPC Class Codes: A61F 2013/00744 containing non-woven
• CPC Class Codes: A61F 2013/00927 with biological activity, e.g. enzymes for debriding wounds or others, collagen or growth factors
• CPC Class Codes: A61F 2013/00931 chitin
• CPC Class Codes: A61L 15/18 containing inorganic materials
• CPC Class Codes: A61L 15/42 Use of materials characterised by their function or physical properties liquid bandages A61L26/00
• CPC Class Codes: A61L 17/145 Coating
• CPC Class Codes: A61L 2400/04 Materials for stopping bleeding
• CPC Class Codes: A61L 2400/12 Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
• CPC Class Codes: A61L 26/0004 containing inorganic materials
• CPC Class Codes: A61L 26/0095 : Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
• CPC Class Codes: A61L 31/082 : Inorganic materials
• CPC Class Codes: A61L 31/128 : containing other specific inorganic fillers not covered by A61L31/126 or A61L31/127
• CPC Class Codes: D06M 23/08 : Processes in which the treating agent is applied in powder or granular form adhesives for multi-layer textile fabrics D06M17/00

Abstract

Methods, systems, and apparatuses for nanomaterial-enhanced hemostatic medical devices are provided. Hemostatic materials and structures are provided that induce coagulation of blood at a wound/opening caused by trauma, a surgical procedure, ulceration, or other cause. The hemostatic materials and structures may incorporate nanostructures and/or further hemostatic elements such as polymers and/or glass beads. The hemostatic materials and structures may be resorbable. Example embodiments include hemostatic bandages, hemostatic plugs, and hemostatic formulations.

Claims

1. A hemostatic structure, comprising:

a base structure that includes a first material; and

a plurality of nanostructures incorporated with the base structure, wherein the nanostructures include at least one of nanofibers or nanorods;

wherein the nanostructures comprise at least one semiconductor material and are configured to induce hemostasis when the hemostatic structure is contacted with blood.

2. The hemostatic structure of claim 1, wherein the base structure includes a woven or nonwoven fiber of the first material.

3. The hemostatic structure of claim 2, wherein the first material is a natural fiber.

4. The hemostatic structure of claim 2, wherein the first material is a synthetic fiber.

5. The hemostatic structure of claim 2, wherein the fiber is a glass microfiber.

6. The hemostatic structure of claim 1, wherein the nanostructures include silicon nanowires.

7. The hemostatic structure of claim 6, wherein the silicon nanowires have a thin naturally occurring oxide shell layer.

8. The hemostatic structure of claim 1, wherein the nanostructures coat the base structure.

9. The hemostatic structure of claim 1, wherein the first material is resorbable.

10. The hemostatic structure of claim 1, wherein the first material includes cotton.

11. The hemostatic structure of claim 1, wherein the first material includes oxidized cellulose.

12. The hemostatic structure of claim 1, wherein the first material includes collagen.

13. The hemostatic structure of claim 1, wherein the first material includes a biologically-derived material.

14. The hemostatic structure of claim 1, wherein the first material is an organic or inorganic polymer.

15. The hemostatic structure of claim 1, wherein the hemostatic structure is a bandage.

16. The hemostatic structure of claim 1, wherein the base structure is a bandage.

17. A hemostat, comprising:

a material; and

a plurality of nanostructures comprising at least one semiconductor material, wherein the nanostructures include at least one of nanofibers, nanorods, or nanotubes;

wherein the material and the nanostructures form a mixture.

18. The hemostat of claim 17, wherein the nanostructures include nanofibers.

19. The hemostat of claim 18, wherein the nanofibers are coated with silicon dioxide.

20. The hemostat of claim 18, wherein the nanofibers are potassium nanofibers.

21. The hemostat of claim 18, wherein the nanofibers are silicon nanofibers functionalized with potassium.

22. The hemostat of claim 17, wherein the material comprises chitosan.

23. The hemostat of claim 22, wherein the material comprises chitosan microparticles.

24. The hemostat of claim 17, wherein the material comprises biocompatible polymers.

25. A method for forming a hemostatic structure, comprising:

incorporating nanostructures with a first material to form the hemostatic structure.

26. The method of claim 25, wherein said incorporating comprises:

incorporating the nanostructures with a weave of fibers of the first material to form the hemostatic structure; and

coating the weave of fibers with the nanostructures to form the hemostatic structure; and

wherein said coating comprises;

sonicating a wafer coated with nanostructures in a liquid;

filtering the sonicated nanostructures;

suspending the filtered nanostructures in a liquid to form a nanostructure suspension;

soaking the weave of fibers in the nanostructure suspension; and

drying the soaked weave of fibers.